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New approaches for fibrosis regression in alcoholic cirrhosis

Journal

HEPATOLOGY INTERNATIONAL
Volume 10, Issue 5, Pages 773-778

Publisher

SPRINGER
DOI: 10.1007/s12072-016-9752-3

Keywords

Fibrosis; Liver; Inflammatory

Funding

  1. NIDDK NIH HHS [T32 DK007356] Funding Source: Medline
  2. BLRD VA [I01 BX000289] Funding Source: Medline
  3. VA [548535, 1I01BX000289-01A2] Funding Source: Federal RePORTER

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Liver fibrosis is a dynamic process of fibrinogenesis and fibrinolysis. It is sequelae of recurrent injury and inflammation to the liver. Only recently has there been significant progress in understanding the pathophysiology behind liver fibrosis. This has allowed for the development of identifiable targets for potential therapies. In this article we will discuss the underlying general cellular mechanisms that play a key role in the pathway of fibrinogenesis and fibrinolysis and then focus on the mechanisms that are key in alcohol-induced liver fibrosis. Challenges in formulating potential fibrosis therapies as well as current potential targets for liver fibrosis will be reviewed as well.

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