Journal
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY
Volume 33, Issue 5, Pages 546-554Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ajoms.2021.02.003
Keywords
Oral cancer; Potentially malignant disorders; Metabolomics; Salivary Metabolites Liquid chromatography; Nuclear mass spectroscopy
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Salivary metabolomics shows potential in the diagnosis of oral cancer and precancer, allowing for exploration of metabolic characteristics, unraveling pathogenesis, and developing targeted therapies.
Early detection of Oral Cancer (OC) with non-invasive tools and screening of high-risk populations remains to be an unmet need. Metabolic reprogramming is an important hallmark of cancer. This review discusses the role of Salivary metabolomics (SM) in the diagnosis of OC and precancer. An electronic search was carried out in various databases with keywords Salivary Metabolomics Oral Cancer Oral leukoplakia and Oral Lichen planus from 2005 to July 2020. A total number of 48 studies were included out of which 38 were excluded. Several characteristic salivary metabolites were significantly altered in OC and precancer patients. SM techniques can be used to explore the metabolic signatures in OC and precancer, unravel its pathogenesis and develop targeted therapies. (C) 2021 Asian AOMS, ASOMP, JSOP, JSOMS, JSOM, and JAMI. Published by Elsevier Ltd. All rights reserved.
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