Journal
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
Volume 30, Issue 5, Pages 1099-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.hoc.2016.05.007
Keywords
Intrinsic pathway; Contact activation; Thrombosis; Factor XI; Factor XII
Categories
Funding
- NIH [HL58837, HL81326]
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Plasma coagulation in the activated partial thromboplastin time assay is initiated by sequential activation of coagulation factors XII, XI, and IX. While this series of proteolytic reactions is not an accurate model for hemostasis in vivo, there is mounting evidence that factor XI and factor XII contribute to thrombosis, and that inhibiting them can produce an antithrombotic effect with a small effect on hemostasis. This article discusses the contributions of components of the intrinsic pathway to thrombosis in animal models and humans, and results of early clinical trials of drugs targeting factors IX, XI, and XII.
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