Journal
CARDIOLOGY AND THERAPY
Volume 10, Issue 2, Pages 349-375Publisher
SPRINGER LONDON LTD
DOI: 10.1007/s40119-021-00231-9
Keywords
Cerebrovascular disease; Ischemic stroke; Ischemia-reperfusion; Sleep; Genetics; Clock genes; Sleep disorders; Cardiovascular risk; Cardiovascular prevention; Circadian rhythms
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This review summarizes the available data on the genetic factors linking ischemic stroke and sleep. Sleep patterns have a genetic component, with potential links to ischemic stroke risk, including variants of circadian genes, neurotransmitter systems, cardiovascular risk factors, and specific genetic factors related to certain sleep disorders.
This review summarizes the available data about genetic factors which can link ischemic stroke and sleep. Sleep patterns (subjective and objective measures) are characterized by heritability and comprise up to 38-46%. According to Mendelian randomization analysis, genetic liability for short sleep duration and frequent insomnia symptoms is associated with ischemic stroke (predominantly of large artery subtype). The potential genetic links include variants of circadian genes, genes encoding components of neurotransmitter systems, common cardiovascular risk factors, as well as specific genetic factors related to certain sleep disorders.
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