Journal
HELVETICA CHIMICA ACTA
Volume 99, Issue 9, Pages 681-686Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/hlca.201600125
Keywords
Docyniaindica; Rosaceae; Docynicasides A - C; Anti-inflammatory activities
Categories
Funding
- National Program for Tay Bac, VNU Hanoi [KHCN-TB.04C/13-18]
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Using various chromatographic methods, three new megastigmane glycosides, docynicasides A-C (1-3) and ten known, (6S,9R)-vomifoliol 9-O--d-xylopyranosyl-(16)-O--d-glucopyranoside (4), hyperin (5), quercitrin (6), quercetin 3--l-arabinofuranoside (7), naringenin 7-O--d-glucopyranoside (8), phloridzin (9), phloretin 2-O--d-xylopyranosyl-(16)--d-glucopyranoside (10), pinosylvin 3-O--d-glucopyranoside (11), tormentic acid (12), and chlorogenic acid methyl ester (13) were isolated from the fruits of Docyniaindica. Their chemical structures were elucidated by physical and chemical methods. All the isolated compounds were evaluated for the inhibitory activity on NO production in LPS-stimulated BV2 cells. As the results, compounds 3-5 showed significant inhibitory activity on LPS-stimulated NO production in BV2 cells with the IC50 values ranging from 21.0 to 29.3m.
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