Journal
CASE REPORTS IN DERMATOLOGY
Volume 13, Issue 2, Pages 432-436Publisher
KARGER
DOI: 10.1159/000517256
Keywords
Darier's disease; Disease flare; Genodermatosis; COVID-19 vaccine; Vaccination
Categories
Ask authors/readers for more resources
Darier's disease is a rare genodermatosis characterized by papules and nail abnormalities, typically not inflammatory in nature but triggered by external factors such as sun exposure, friction, or infection. A case report discusses a flare of Darier's disease following COVID-19 vaccination, considering possible mechanisms linking the two and emphasizing the need for awareness among clinicians due to the close temporal association.
Darier's disease is a rare genodermatosis characterized clinically by dyskeratotic papules in the seborrheic and intertriginous areas and nail abnormalities. Dyskeratosis and acantholysis are typical histological findings. Darier's disease is not known to be inflammatory by nature as inflammation occurs primarily due to local infections, and it may therefore differ from inflammatory dermatoses such as psoriasis and cutaneous lupus in response to antigen stimulation. Known triggers of Darier's disease primarily include exogenous factors such as sun exposure, friction, or infection. We present a case of a 47-year-old white female with a flare of Darier's disease 2 days following her first vaccination with COVID-19 vaccine (ChAdOx1-s [recombinant]) (Vaxzevria (R) [previously known as COVID-19 vaccine AstraZeneca]). In this case report, we discuss possible mechanisms linking the vaccination and the flare of Darier's disease. We consider inflammatory mechanisms as well as a random co-occurrence. Due to the close time-related association between the disease flare and the COVID-19 vaccination, we find an urge to make other clinicians aware of a possible association. (C) 2021 The Author(s). Published by S. Karger AG, Basel
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available