Darier's Disease Flare following COVID-19 Vaccine

Darier's disease is a rare genodermatosis characterized clinically by dyskeratotic papules in the seborrheic and intertriginous areas and nail abnormalities. Dyskeratosis and acantholysis are typical histological findings. Darier's disease is not known to be inflammatory by nature as inflammation occurs primarily due to local infections, and it may therefore differ from inflammatory dermatoses such as psoriasis and cutaneous lupus in response to antigen stimulation. Known triggers of Darier's disease primarily include exogenous factors such as sun exposure, friction, or infection. We present a case of a 47-year-old white female with a flare of Darier's disease 2 days following her first vaccination with COVID-19 vaccine (ChAdOx1-s [recombinant]) (Vaxzevria (R) [previously known as COVID-19 vaccine AstraZeneca]). In this case report, we discuss possible mechanisms linking the vaccination and the flare of Darier's disease. We consider inflammatory mechanisms as well as a random co-occurrence. Due to the close time-related association between the disease flare and the COVID-19 vaccination, we find an urge to make other clinicians aware of a possible association. (C) 2021 The Author(s). Published by S. Karger AG, Basel

Automated summary

Darier's disease is a rare genodermatosis characterized by papules and nail abnormalities, typically not inflammatory in nature but triggered by external factors such as sun exposure, friction, or infection. A case report discusses a flare of Darier's disease following COVID-19 vaccination, considering possible mechanisms linking the two and emphasizing the need for awareness among clinicians due to the close temporal association.