Bioactive Secondary Metabolites from the Mangrove Endophytic Fungi Nigrospora oryzae

Mangrove forest has a distinctive habitat adapting with marine and terrestrial environment. Chemical investigation of the extract from mangrove endophytic fungi Nigrospora oryzae had resulted in the isolation of sterigmatocystin (1) and pestalopyrone (2). The structure of sterigmatocystin (1) and pestalopyrone (2) were elucidated using mass, UV and NMR spectrometers together with the comparison with the literature data. The study also showed that sterigmatocystin displayed moderate cytotoxicity but it could be further developed as antiviral and antibacterial agent based on the SAR information reported from its analogue and derivatives.

Automated summary

Chemical investigation of extract from mangrove endophytic fungi resulted in isolation of sterigmatocystin and pestalopyrone. Sterigmatocystin displayed moderate cytotoxicity and potential as antiviral and antibacterial agent based on SAR information.