Electrophysiological Studies of Reception of Facial Communication in Autism Spectrum Disorder and Schizophrenia

Autism spectrum disorder (ASD) and schizophrenia spectrum disorders (SZ) are characterized by difficulty with social cognition and atypical reception of facial communication-a key area in the Research Domain Criteria framework. To identify areas of overlap and dissociation between ASD and SZ, we review studies of event-related potentials (ERP) to faces across ASD and SZ populations, focusing on ERPs implicated in social perception: P100, N170, N250, and P300. There were many inconsistent findings across studies; however, replication was strongest for delayed N170 latency in ASD and attenuated N170 amplitude in SZ. These results highlight the challenges of replicating research findings in heterogeneous clinical populations and the need for transdiagnostic research that continuously quantifies behavior and neural activity across neurodevelopmental disorders.

Automated summary

This study reviewed research on event-related potentials (ERP) to faces in Autism Spectrum Disorder (ASD) and Schizophrenia Spectrum Disorders (SZ), finding both overlap and differences between ASD and SZ. ASD and SZ show different characteristics in face ERPs, highlighting the importance of transdiagnostic research in neurodevelopmental disorders.