Journal
BMJ OPEN GASTROENTEROLOGY
Volume 8, Issue 1, Pages -Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/bmjgast-2021-000640
Keywords
hydrogen breath tests; intestinal malabsorption; bacterial infection
Categories
Ask authors/readers for more resources
Most patients can deliver high quality end-expiratory breath samples, regardless of age or gender. The correction factor algorithm is unreliable in predicting the end-expiratory result at 15% O-2, resulting in false negative results for 50% of positive cases in this study. Continuous O-2 measurement is essential to ensure breath sample quality by preventing secondary breathing during real-time breath collection.
Objective A high quality end-expiratory breath sample is required for a reliable gastrointestinal breath test result. Oxygen (O-2) concentration in the breath sample can be used as a quality marker. This study investigated the characteristics of O-2 concentration in the breath sample and the impact of using a correction factor in real-time breath measurement. Design This study includes two separate groups of patient data. Part 1 of the study analysed the patient's ability to deliver end-expiratory breath samples over a 2-year period (n=564). Part 2 of the study analysed a separate group of patients (n=47) with additional data to investigate the O-2 characteristics and the role of correction factor in breath test. Results The results indicated 95.4% of 564 patients were able to achieve an O-2 concentration below 14% in their end-expiratory breath. Part 2 of the study revealed that the distribution of O-2 concentration was between 9.5% and 16.2%. Applying a correction factor to predict the end-expiratory H-2 and CH4 values led to an average measurement error of -36.4% and -12.8%, respectively. Conclusion The majority of patients are able to deliver a high quality end-expiratory breath sample, regardless of age or gender. The correction factor algorithm is unreliable when predicting the end-expiratory result at 15% O-2 and it would have resulted in false negative result for 50% of the positive cases in this study. It has also indicated that the continuous O-2 measurement is essential to ensure breath sample quality by preventing secondary breathing during real-time breath collection.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available