3.8 Article

Levoketoconazole: a novel treatment for endogenous Cushing's syndrome

Related references

Note: Only part of the references are listed.
Article Endocrinology & Metabolism

Levoketoconazole, the 2S,4R Enantiomer of Ketoconazole, a New Steroidogenesis Inhibitor for Cushing's Syndrome Treatment

Sara G. Creemers et al.

Summary: This study compared the effects of Levoketoconazole and RK on adrenocortical and pituitary adenoma cells, with Levoketoconazole showing more potent inhibition of cortisol production and a more significant effect on steroid profiles. Levoketoconazole also demonstrated potential in inhibiting ACTH secretion and growth of pituitary adenoma cells, suggesting it as a promising novel pharmacotherapy for Cushing's syndrome.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

Article Endocrinology & Metabolism

Levoketoconazole improves clinical signs and symptoms and patient-reported outcomes in patients with Cushing's syndrome

Eliza B. Geer et al.

Summary: The study demonstrated significant improvements in skin symptoms and patient-reported quality of life and depression symptoms in patients with CS treated with levoketoconazole during the maintenance phase.

PITUITARY (2021)

Review Endocrinology & Metabolism

Updates in adrenal steroidogenesis inhibitors for Cushing's syndrome - A practical guide

Elena V. Varlamov et al.

Summary: Medical therapy with steroidogenesis inhibitors is crucial in managing patients with Cushing's syndrome when surgery is not an option, failed, or recurrence occurs. Among these inhibitors, osilodrostat has shown high efficacy and has been approved for treating Cushing's disease by the FDA and CS by the EMA. Other options like metyrapone, ketoconazole, and etomidate lack prospective evaluations but have shown varied efficacy in treating CS patients.

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

Review Endocrinology & Metabolism

Cardiovascular risk assessment, thromboembolism, and infection prevention in Cushing?s syndrome: a practical approach

Elena V. Varlamov et al.

Summary: Cushing's syndrome is associated with increased mortality due to cardiovascular, thromboembolic, and infection complications. Treatment should focus on managing a range of cardiovascular risk factors and may require medical therapy even before surgery in severe cases. Treatment adjustments should be based on disease pathophysiology and drug-drug interactions.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2021)

Article Endocrinology & Metabolism

Levoketoconazole in the Treatment of Patients With Cushing's Syndrome and Diabetes Mellitus: Results From the SONICS Phase 3 Study

Rosario Pivonello et al.

Summary: Treatment with levoketoconazole resulted in sustained normalization of mUFC levels and improvement in glycemic control, with more pronounced effects in patients with diabetes mellitus.

FRONTIERS IN ENDOCRINOLOGY (2021)

Review Endocrinology & Metabolism

Adrenally Directed Medical Therapies for Cushing Syndrome

Nicholas A. Tritos

Summary: Endogenous Cushing syndrome, characterized by excess cortisol secretion, may require adrenally directed medical therapies when surgery is not feasible or ineffective. Different drugs are available for the treatment of CS, each with varying mechanisms of action and considerations for dosage titration and patient monitoring. Proper use of these medications is crucial for the management of persistent or recurrent hypercortisolism in CS patients.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

Article Endocrinology & Metabolism

Use of late-night salivary cortisol to monitor response to medical treatment in Cushing's disease

John Newell-Price et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2020)

Review Endocrinology & Metabolism

Advances in the medical treatment of Cushing's syndrome

Richard A. Feelders et al.

LANCET DIABETES & ENDOCRINOLOGY (2019)

Review Endocrinology & Metabolism

Therapeutic options after surgical failure in Cushing's disease: A critical review

German Rubinstein et al.

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2019)

Article Endocrinology & Metabolism

The incidence of endogenous Cushing's syndrome in the modern era

Sofie Wengander et al.

CLINICAL ENDOCRINOLOGY (2019)

Review Pharmacology & Pharmacy

Medical Management of Cushing's Syndrome: Current and Emerging Treatments

Jose Miguel Hinojosa-Amaya et al.

DRUGS (2019)

Article Endocrinology & Metabolism

Radiotherapy as a tool for the treatment of Cushing's disease

Frederic Castinetti et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2019)

Article Oncology

Effects of Ketoconazole on ACTH-Producing and Non-ACTH-Producing Neuroendocrine Tumor Cells

Aura D. Herrera-Martinez et al.

HORMONES & CANCER (2019)

Article Endocrinology & Metabolism

Medical Therapy for Cushing's Syndrome in the Twenty-first Century

Nicholas A. Tritos et al.

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA (2018)

Article Endocrinology & Metabolism

Hepatic safety of ketoconazole in Cushing's syndrome: results of a Compassionate Use Programme in France

Jacques Young et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2018)

Article Endocrinology & Metabolism

Efficacy and safety of once-monthly pasireotide in Cushing's disease: a 12 month clinical trial

Andre Lacroix et al.

LANCET DIABETES & ENDOCRINOLOGY (2018)

Review Endocrinology & Metabolism

Diabetes Mellitus Secondary to Cushing's Disease

Mattia Barbot et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

Review Chemistry, Medicinal

Transporters Involved in Metformin Pharmacokinetics and Treatment Response

Xiaomin Liang et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2017)

Review Endocrinology & Metabolism

Diabetes in Cushing Disease

G. Mazziottil et al.

CURRENT DIABETES REPORTS (2017)

Article Pharmacology & Pharmacy

No Untoward Effect of Long-Term Ketoconazole Administration on Electrocardiographic QT Interval in Patients with Cushing's Disease

Martina De Martin et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2016)

Article Chemistry, Medicinal

Design, synthesis, and evaluation of (2S, 4R)-Ketoconazole sulfonamide analogs as potential treatments for Metabolic Syndrome

Benjamin E. Blass et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)

Review Endocrinology & Metabolism

Complications of Cushing's syndrome: state of the art

Rosario Pivonello et al.

LANCET DIABETES & ENDOCRINOLOGY (2016)

Review Endocrinology & Metabolism

The Treatment of Cushing's Disease

Rosario Pivonello et al.

ENDOCRINE REVIEWS (2015)

Review Endocrinology & Metabolism

A critical reappraisal of bilateral adrenalectomy for ACTH-dependent Cushing's syndrome

Martin Reincke et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2015)

Article Endocrinology & Metabolism

Treatment of Cushing's Syndrome: An Endocrine Society Clinical Practice Guideline

Lynnette K. Nieman et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2015)

Article Endocrinology & Metabolism

Effectiveness of Metyrapone in Treating Cushing's Syndrome: A Retrospective Multicenter Study in 195 Patients

Eleni Daniel et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2015)

Article Medicine, General & Internal

Cushing's syndrome

Andre Lacroix et al.

LANCET (2015)

Review Neurosciences

Neuropsychiatric disorders in Cushing's syndrome

Rosario Pivonello et al.

FRONTIERS IN NEUROSCIENCE (2015)

Editorial Material Endocrinology & Metabolism

Ketoconazole as an Adrenal Steroidogenesis Inhibitor: Effectiveness and Risks in the Treatment of Cushing's Disease

John Newell-Price

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2014)

Article Endocrinology & Metabolism

Ketoconazole in Cushing's Disease: Is It Worth a Try?

Frederic Castinetti et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2014)

Article Endocrinology & Metabolism

Multisystem Morbidity and Mortality in Cushing's Syndrome: A Cohort Study

Olaf M. Dekkers et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2013)

Article Endocrinology & Metabolism

Efficiency and tolerance of mitotane in Cushing's disease in 76 patients from a single center

Camille Baudry et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2012)

Review Primary Health Care

Cushing Syndrome: Maybe Not So Uncommon of an Endocrine Disease

Federica Guaraldi et al.

JOURNAL OF THE AMERICAN BOARD OF FAMILY MEDICINE (2012)

Article Medicine, General & Internal

A 12-Month Phase 3 Study of Pasireotide in Cushing's Disease

Annamaria Colao et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Review Biochemistry & Molecular Biology

Circadian rhythm of adrenal glucocorticoid: Its regulation and clinical implications

Sooyoung Chung et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2011)

Review Pharmacology & Pharmacy

Ketoconazole enantiomer for the treatment of diabetes mellitus

Richard Arakaki et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2010)

Letter Medicine, General & Internal

Pasireotide Alone or with Cabergoline and Ketoconazole in Cushing's Disease

Richard A. Feelders et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Review Biochemistry & Molecular Biology

Bile acids: regulation of synthesis

John Y. L. Chiang

JOURNAL OF LIPID RESEARCH (2009)

Article Pharmacology & Pharmacy

Coexistence of hERG current block and disruption of protein trafficking in ketoconazole-induced long QT syndrome

H. Takemasa et al.

BRITISH JOURNAL OF PHARMACOLOGY (2008)

Article Endocrinology & Metabolism

Ketoconazole revisited: a preoperative or postoperative treatment in Cushing's disease

F. Castinetti et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2008)

Article Endocrinology & Metabolism

Effect of one month ketoconazole treatment on GH, cortisol and ACTH release after ghrelin, GHRP-6 and GHRH administration in patients with Cushing's disease

Silvia R. Correa-Silva et al.

ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA (2007)