Journal
OPEN HEART
Volume 8, Issue 2, Pages -Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/openhrt-2021-001777
Keywords
epidemiology; risk factors; coronary artery disease
Categories
Funding
- Northern Norway Health Authority [HNF1363-17]
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The study compared the population proportion at high risk of cardiovascular disease using different prediction methods and guidelines. The revised NORRISK 2 score and guidelines led to an increase in the population proportion eligible for intervention from 2009 to 2017.
Aims To compare the population proportion at high risk of cardiovascular disease (CVD) using the Norwegian NORRISK 1 that predicts 10-year risk of CVD mortality and the Norwegian national guidelines from 2009, with the updated NORRISK 2 that predicts 10-year risk of both fatal and non-fatal risk of CVD and the Norwegian national guidelines from 2017. Methods We included participants from the Norwegian population-based Tromso Study (2015-2016) aged 40-69 years without a history of CVD (n=16 566). The total proportion eligible for intervention was identified by NORRISK 1 and the 2009 guidelines (serum total cholesterol >= 8 mmol/L, systolic blood pressure >= 160 mm Hg or diastolic blood pressure >= 100 mm Hg) and NORRISK 2 and the 2017 guidelines (serum total cholesterol >= 7 mmol/L, low density lipoprotein (LDL) cholesterol >= 5 mmol/L, systolic blood pressure >= 160 mm Hg or diastolic blood pressure >= 100 mm Hg). Results The total proportion at high risk as defined by a risk score was 12.0% using NORRISK 1 and 9.8% using NORRISK 2. When including single risk factors specified by the guidelines, the total proportion eligible for intervention was 15.5% using NORRISK 1 and the 2009 guidelines and 18.9% using NORRISK 2 and the 2017 guidelines. The lowered threshold for total cholesterol and specified cut-off for LDL cholesterol stand for a large proportion of the increase in population at risk. Conclusion The population proportion eligible for intervention increased by 3.4 percentage points from 2009 to 2017 using the revised NORRISK 2 score and guidelines.
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