Journal
HEALTH AND QUALITY OF LIFE OUTCOMES
Volume 14, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12955-016-0480-0
Keywords
Health-related quality of life; QOL-NPC; Reliability; Validity; Responsiveness
Funding
- National Natural Science Foundation of China [81272575, 81403296]
- Science and Technology Planning Project of Guangdong Province [2012B031800301]
- Medical Scientific Research Foundation of Guangdong Province [B2013163]
- Outstanding Youth Foundation of Guangdong Province colleges and universities [YQ2015041]
- Young Talents Foundation of Guangzhou University of Chinese medicine [QNYC20140101]
- Torch Plan of Guangzhou University of Chinese Medicine [XH20140105]
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Background: The aim was to develop and validate the quality of life scale for nasopharyngeal carcinoma (NPC) patients, the QOL-NPC (version 2), a specific instrument to measure quality of life for NPC patients. Methods: The QOL-NPC was developed and validated according to standard procedures. The patients were assessed using the QOL-NPC, FACT-G, and FACT-H&N. Classical test theory was used to evaluate the reliability, validity, and responsiveness of the QOL-NPC. Results: A total of 487 patients (97.4 %) completed the questionnaire. The QOL-NPC comprised four domains, as follows: physical function (eight items); psychological function (five items); social function (five items); and side effects (eight items). All of the items had a lower proportion of missing data. Cronbach's alpha values of the domains ranged from 0.72 to 0.84. The split-half reliability coefficients ranged from 0.77 to 0.84. All of the intra-class correlation coefficients were > 0.8. The normed fit index, non-normed fit index, and comparative fit index were > 0.89. The root mean square error of approximation was 0.097, with a 90 % confidence interval (0.093, 0.100). The domain scores of the QOL-NPC were significantly correlated with the FACT-G and FACT-H& N (P < 0.05). All of the domain scores of patients using different amounts of radiotherapy were significantly different (P < 0.001). All domain scores decreased at the completion of radiotherapy, with effect sizes ranging from -0.82 to -0.22. Conclusions: The QOL-NPC is valid for measuring QOL with good reliability, validity, and responsiveness. The QOL-NPC is recommended to measure the QOL for Chinese NPC patients.
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