Journal
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Volume 39, Issue 1, Pages 133-139Publisher
WILEY-BLACKWELL
DOI: 10.1002/hed.24559
Keywords
anaplastic thyroid carcinoma; prognostic factor; surgery; multimodal treatment; multicenter study
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Funding
- Research committee in Korean Society of Thyroid Head and Neck Surgery
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Background. The Korean Society of Thyroid Head and Neck Surgery established a nationwide multicenter registry of anaplastic thyroid carcinoma (ATC) and evaluated the prognostic factors and treatment outcomes of ATC. Methods. The present study enrolled 329 patients who were diagnosed with ATC between January 2000 and December 2012 at 19 medical centers in Korea. Survival outcomes were evaluated according to various clinical factors and treatments. Results. Multivariate analysis identified age >= 70 years old, the presence of initial clinical symptoms, distant metastasis, and treatment modality as significant risk factors (p < .05). The patients who underwent curative resection and adjuvant radiotherapy (RT) or concurrent chemoradiotherapy (CRT) showed the best survival on multivariate analysis (p < 0.05). Conclusion. Although ATC is a lethal neoplasm, long-term survival may be acquired in cases in which the aggressive management, including curative resection or RT/concurrent CRT, is possible for therapeutic intent. (C) 2016 Wiley Periodicals, Inc.
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