Journal
HELIYON
Volume 7, Issue 8, Pages -Publisher
CELL PRESS
DOI: 10.1016/j.heliyon.2021.e07777
Keywords
Antivirals; Covid-19; Diterpenes; Pandemic; SARS-CoV-2; Infectious diseases
Categories
Funding
- Hibah Riset Mandat Kolaborasi Mitra Luar NegeriUniversitas Airlangga 2021 [800/UN3.15/PT/2021]
Ask authors/readers for more resources
Viruses can cause widespread diseases leading to pandemics. Countries are racing to develop antivirals to combat the current Covid-19 pandemic caused by SAR-CoV-2 infection. Diterpene compounds derived from natural sources and synthetic products show potential as antivirals, targeting various viruses including SARS-CoV-2.
Viruses cause widely transmitted diseases resulting in pandemic conditions. Currently, the world is being hit by the Covid-19 pandemic caused by the SAR-CoV-2 infection. Countries in the world are competing to develop antivirals to overcome this problem. Diterpene compounds derived from natural ingredients (plants, corals, algae, fungi, sponges) and synthesized products have potential as antivirals. This article summarizes the different types of diterpenes such as daphnane, tiglilane, kaurane, abietane, pimarane, labdane, dollabelane, jatrophane, dolastane, prenylated guaiane, tonantzitlolone, casbane, have antivirals activity such as targeting HIV, Coxsackie virus, herpes virus, hepatitis virus, influenza virus, Chikungunya virus, Zika virus, dengue virus, and SARS-CoV. Some compounds such as andrographolide and its derivatives show promising activity in inhibiting the influenza virus. Additionally, compounds such as pineolidic acid, forskolin, sugiol, and many other diterpene compounds showed anti-SAR-CoV activity. The diterpene compound class's high antivirals potential does not rule out the possibility that these compounds can also act as anti-SAR-CoV-2 drugs in the future.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available