Journal
AIDS AND BEHAVIOR
Volume 26, Issue 4, Pages 1138-1152Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10461-021-03467-7
Keywords
HIV; Alcohol use; Drug use; Medication adherence; Motivational interviewing; Cognitive behavioral therapy
Funding
- National Institute for Alcohol Abuse Alcoholism [R01 AA022302]
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The study evaluated the effectiveness of Project PLUS, a 6-session intervention, in reducing substance use and improving ART adherence among PLWH. However, the results did not show significant intervention effects, which may have been limited by the quasi-experimental design, high quality of standard care at the clinics, or inadequate intervention dose.
This study evaluated the effectiveness of Project PLUS, a 6-session Motivational Interviewing and Cognitive Behavioral intervention to reduce substance use and improve antiretroviral therapy (ART) adherence among PLWH. In a quasi-experimental design, 84 participants from a network of three comprehensive care clinics in New York City received the intervention immediately post-baseline (the Immediate condition) and 90 were assigned to a Waitlist control. Viral load and CD4 data were extracted from electronic medical records (EMR) for a No-Intervention comparison cohort (n = 120). Latent growth curve analyses did not show a consistent pattern of significant between-group differences post-intervention or across time in ART adherence or substance use severity between Immediate and Waitlist participants. Additionally, Immediate intervention participants did not differ significantly from the Waitlist or No-Treatment groups on viral load or CD4 post-intervention or across time. The potential to detect intervention effects may have been limited by the use of a quasi-experimental design, the high quality of standard care at these clinics, or inadequate intervention dose. Trial Registration: ClinicalTrials.gov (NIH U.S. National Library of Medicine) Identifier: NCT02390908; https://clinicaltrials.gov/ct2/show/NCT02390908.
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