The Development of Pharmacological Therapies for Alzheimer's Disease

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that currently has no cure. The aged population is growing globally, creating an urgent need for more promising therapies for this debilitating disease. Much effort has been made in recent decades, and the field is highly dynamic, with numerous trials. The main focus of these trials includes disease modification and symptomatic treatment. Some have shown beneficial outcomes, while others have shown no significant benefits. Here, we cover the outcome of recently published AD clinical trials, as well as the mechanism of action of these therapeutical agents, to re-think drug development strategies and directions for future studies.

Automated summary

Alzheimer's disease is a progressive neurodegenerative disorder without a cure. There is a growing need for more promising therapies due to the increasing elderly population worldwide. Recent efforts in clinical trials have focused on disease modification and symptomatic treatment, with varying results reported. The outcome of these trials and mechanisms of therapeutic agents are critical for guiding future drug development strategies.