Synthesis and properties of polypeptoid-containing block copolymers: A review

Polypeptoids, with similar structure to polypeptides, are nowadays rising stars due to their excellent solubility, processibility, enzymatic stability, and biocompatibility. Attractive properties of polypeptoid-containing copolymers endow them with various applications in surface antifouling, biosensing, microreactor, drug delivery, and stimuli-response. The syntheses of block copolymers containing polypeptoids have attracted a great amount of interest so far. The review summarizes the synthetic strategies of polypeptoid-containing copolymers, that is, polypeptoid-b-polypeptoid, -polypeptide, -polyester, -polyether and -polyolefin developed recently, as well as their phase-separation, assembly and stimuli-response properties.

Automated summary

Polypeptoids, similar in structure to polypeptides, have gained attention for their excellent properties such as solubility, processibility, enzymatic stability, and biocompatibility. Copolymers containing polypeptoids are widely used in surface antifouling, biosensing, microreactor, drug delivery, and stimuli-response applications. The syntheses of block copolymers with polypeptoids have attracted significant interest, focusing on their phase-separation, assembly, and stimuli-response properties.