Journal
ACS APPLIED POLYMER MATERIALS
Volume 3, Issue 10, Pages 5236-5242Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsapm.1c01015
Keywords
NIR-II; small-molecule nanoparticles; reduced intermolecular interaction; enhanced NIR-II fluorescence; targeted inflammation imaging
Funding
- National Natural Science Foundation of China [21604042, 21674048]
- Natural Science Foundation of Jiangsu Province [BK20201380]
- Postgraduate Research and Innovation Project of Jiangsu Province [KYCX20_0751]
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Bright NIR-II fluorescent small-molecule NPs were successfully prepared in the study, showing superior fluorescence performance in vitro. The TQFPN was successfully applied for targeted in vivo inflammation imaging, providing high-resolution imaging for mouse models.
Though biocompatible small-molecule-based NIR-II fluorescent nanoparticles (NPs) are highly desirable in fluorescence imaging (FI), the fluorescence quantum yield is relatively poor due to the significant aggregation-caused quenching and the heavy intermolecular interactions. Herein, we conveniently obtained bright NIR-II fluorescent small-molecule NPs (TQFPNs) fabricated from a polystyrene (PS)-modified fluorophore (TQF-PS). Our prepared PS-modified NPs displayed 3.2-fold higher emission intensity than that of non-PS polymer chain NPs (TQF@NPs) in vitro. Finally, bright and high-resolution NIR-II FI of a rheumatoid arthritis mouse model and a pneumonia mouse model using TQFPNs demonstrated its successful application for targeted in vivo inflammation imaging.
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