4.7 Article

Design of Electrochemically Reduced Graphene Oxide/Titanium Disulfide Nanocomposite Sensor for Selective Determination of Ascorbic Acid

Journal

ACS APPLIED NANO MATERIALS
Volume 4, Issue 10, Pages 10077-10089

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acsanm.1c01464

Keywords

ascorbic acid; erGO/TiS2; biosensor; HPLC-MS; validation

Funding

  1. DST-SERB, India [CRG/2020/001973]
  2. National Research Foundation of Korea [NRF-2015R1A5A1036133]

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The study introduces a novel sensing platform utilizing erGO/TiS2 NC for detecting ascorbic acid with high sensitivity and selectivity. The sensor demonstrates satisfactory reliability for recovery of AA and can be considered for the diagnosis of clinical samples.
Synthesizing conductive nanocomposites (NCs) for realizing an ultrasensitive biosensor is a prevalent technological thrust. Herein, a simple and unusual design of a sensing platform is documented using electrochemically reduced graphene oxide/titanium disulfide nanocomposite (erGO/TiS2 NC) for detection of ascorbic acid (AA): a significant neurobiological molecule. The NC is designed via sonolysis of a solution comprising ex situ-synthesized GO and TiS2 and subsequently electrochemically reduced for fabricating the sensing interface. Advanced analytical studies are carried out to support the construction of the erGO/TiS2//glassy carbon electrode (GCE). Under the optimal measuring conditions, the sensor offers two linear responses within (i) 0.1 -> 1 mu M, a limit of detection (LoD) of 30.2 nM (S/N = 3) and a sensitivity of 0.34 mu A.mu M-1.cm(-2), and (ii) 1 -> 400 mu M, a LoD of 91.4 nM and a sensitivity of 0.11 mu A.mu M-1.cm(-2) for AA. Moreover, the sensor demonstrates high selectivity toward AA over other bioanalytes except for tiny anodic responses of cysteine (7.5%) and dopamine (8.9%). Finally, the practicability of the proposed sensor has been tested for AA in pharmaceutical and human urine samples and validated by high-performance liquid chromatography-mass spectrometry (HPLC-MS). Overall, the sensor demonstrates satisfactory reliability for recovery of AA and can be considered for the diagnosis of clinical samples.

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