Journal
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
Volume 14, Issue -, Pages 3109-3118Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJGM.S318069
Keywords
obsessive-compulsive disorder; continuous theta-burst stimulation; orbitofrontal cortex; transcranial magnetic stimulation
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The study investigated whether regulating right orbitofrontal cortex activity through cTBS could impact OCD symptoms. However, after two weeks of treatment, there were no significant differences in Y-BOCS scores or other outcome measures between the active and sham groups. While depressive symptoms improved in the active group, this improvement was not sustained at 6 weeks.
Purpose: Examining whether modulation of right orbitofrontal cortex (OFC) activity by continuous theta-burst stimulation (cTBS) affects obsessive-compulsive disorder (OCD) symptoms. Patients and Methods: A total of 28 treatment-resistant OCD participants were treated with either active or sham cTBS of the OFC twice per day, for five days a week, for 2 weeks, in a double-blinded manner. Clinical response to treatment was determined using the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS). Results: There were no statistically significant differences between the 2 groups after two weeks of treatment in the Yale-Brown Obsessive-Compulsive Scale score (group*time interaction, F2,20=0.996, p=0.387) and other secondary outcome measures, including anxiety symptoms and responder rates. Depressive symptoms improved significantly in the active group (p=0.027), but the significant difference disappeared at 6 weeks (p=0.089). Conclusion: This is the first randomized controlled study using cTBS in the right OFC to observe the improvement of treatment-resistant OCD symptoms. It is safe to use cTBS, but 2 weeks of treatment is not enough to achieve a curative effect. Future studies are needed to explore more advanced stimulation parameters suitable for the treatment of OCD.
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