4.4 Article

SARS-CoV-2 infection shortly after BNT162b2 vaccination results in high anti-spike antibody levels in nursing home residents and staff

Journal

IMMUNITY INFLAMMATION AND DISEASE
Volume 9, Issue 4, Pages 1702-1706

Publisher

WILEY
DOI: 10.1002/iid3.525

Keywords

anti-SARS-CoV-2 spike antibodies; COVID-19; SARS-CoV-2; vaccine

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Funding

  1. Volkswagen Foundation [98 579]

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The study found that individuals who were infected as early as 10 days after their first vaccine dose had antibody levels comparable to fully vaccinated individuals.
Introduction One dose of a coronavirus disease 2019 (COVID-19) vaccine can elicit high antibody titers in individuals who were previously infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, it is unclear how a SARS-CoV-2 infection shortly after a first COVID-19 vaccine dose affects antibody responses. Methods Here we investigate residents and staff of a nursing home, where a COVID-19 outbreak occurred shortly after the first BNT162b2 immunization. Results and Conclusions Our data show that individuals who got infected as early as 10 days after their first immunization show antibody levels comparable to fully vaccinated individuals.

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