4.6 Review

Structure and Function of Protein Arginine Methyltransferase PRMT7

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Protein arginine methyltransferases: promising targets for cancer therapy

Jee Won Hwang et al.

Summary: This article discussed the roles of protein arginine methyltransferases (PRMTs) in cancer and their potential as targets in cancer therapy. Aberrant expression of PRMTs is closely related to cancer development, and PRMT inhibitors have shown promise in clinical trials.

EXPERIMENTAL AND MOLECULAR MEDICINE (2021)

Review Biotechnology & Applied Microbiology

Protein arginine methylation: from enigmatic functions to therapeutic targeting

Qin Wu et al.

Summary: PRMTs are emerging as attractive therapeutic targets due to their regulation of essential biological processes such as transcription, splicing, RNA biology, DNA damage response, and cell metabolism, which are often disrupted in diseases. Understanding how these enzymes support cancer cell growth in specific metabolic contexts or in the presence of certain mutations has provided the rationale for targeting them in oncology, with ongoing inhibitor development and in-depth mechanistic investigations guiding future clinical development.

NATURE REVIEWS DRUG DISCOVERY (2021)

Article Biochemistry & Molecular Biology

Arginine and lysine methylation of MRPS23 promotes breast cancer metastasis through regulating OXPHOS

Lingxia Liu et al.

Summary: This study uncovered a unique mechanism of controlling OXPHOS through arginine and lysine methylation, and highlighted the impact of the PRMT7-SETD6-MRPS23 axis during breast cancer metastasis.

ONCOGENE (2021)

Article Multidisciplinary Sciences

Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth

Wen-juan Li et al.

Summary: The study identified numerous substrates for Type I and II arginine methyltransferases and revealed features of PRMT7-regulated methylation, showing it primarily methylates a specific glycine and arginine motif. The study also demonstrated the role of PRMT4/5/7 in cancer-associated splicing regulation and potential as targets for cancer therapy. Pharmacological inhibition of PRMT4/5/7 was shown to suppress cancer cell growth with synergistic effects when co-inhibited.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Symmetrically dimethylated histone H3R2 promotes global transcription during minor zygotic genome activation in mouse pronuclei

Kohtaro Morita et al.

Summary: This study revealed that H3R2me2s promotes global transcription in mice during development, playing a crucial role in minor zygotic genome activation (ZGA).

SCIENTIFIC REPORTS (2021)

Article Biochemistry & Molecular Biology

The role of protein arginine methyltransferase 7 in human developmentally arrested embryos cultured in vitro

Wuwen Zhang et al.

Summary: PRMT7 overexpression disrupts early embryonic development, leading to developmental arrest, but this defect can be partially rescued by PRMT7 knockdown. The increased levels of PRMT7 and H4R3me2s methylation in arrested embryos were observed. Knockdown of PRMT7 could rescue developmentally arrested embryos and result in blastocyst development in some cases.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2021)

Article Biochemistry & Molecular Biology

Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity

Junji Zhu et al.

Summary: PRMT7 regulates MAVS-mediated antiviral response through arginine monomethylation, negatively regulating MAVS activation and ensuring timely antiviral defense activation. Modulation of PRMT7 activity provides insights into mechanisms controlling innate immune response.

MOLECULAR CELL (2021)

Article Biochemical Research Methods

Global analysis of protein arginine methylation

Fangrong Zhang et al.

Summary: Quantitative analysis of protein arginine methylation (ArgMet) using NMR spectroscopy revealed its prevalence and modulation by inhibitors and metabolites, providing insights into its role in health and disease.

CELL REPORTS METHODS (2021)

Article Biochemistry & Molecular Biology

PRMT7 methylates and suppresses GLI2 binding to SUFU thereby promoting its activation

Tuan Anh Vuong et al.

CELL DEATH AND DIFFERENTIATION (2020)

Review Biochemical Research Methods

Chemical probes for protein arginine methyltransferases

Alice Shi Ming Li et al.

METHODS (2020)

Article Multidisciplinary Sciences

Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response

Magdalena M. Szewczyk et al.

NATURE COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

PRMT7 regulates RNA-binding capacity and protein stability in Leishmania parasites

Tiago R. Ferreira et al.

NUCLEIC ACIDS RESEARCH (2020)

Article Genetics & Heredity

Further delineation of the phenotype caused by loss of function mutations in PRMT7

Irene Valenzuela et al.

EUROPEAN JOURNAL OF MEDICAL GENETICS (2019)

Review Biochemistry & Molecular Biology

PRMT7 as a unique member of the protein arginine methyltransferase family: A review

Kanishk Jain et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2019)

Article Biochemistry & Molecular Biology

PRMT7 deficiency enhances adipogenesis through modulation of C/EBP-β

Young-Eun Leem et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Review Biochemistry & Molecular Biology

Protein arginine methyltransferases: insights into the enzyme structure and mechanism at the atomic level

Sunil Kumar Tewary et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2019)

Review Biochemistry & Molecular Biology

Cellular consequences of arginine methylation

Benjamin M. Lorton et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2019)

Review Cell Biology

The regulation, functions and clinical relevance of arginine methylation

Ernesto Guccione et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Review Biochemistry & Molecular Biology

PRMTs and Arginine Methylation: Cancer's Best-Kept Secret?

James Jarrold et al.

TRENDS IN MOLECULAR MEDICINE (2019)

Article Biochemistry & Molecular Biology

Methylation determines the extracellular calcium sensitivity of the leak channel NALCN in hippocampal dentate granule cells

Seul-Yi Lee et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2019)

Article Genetics & Heredity

Prenatal and postnatal presentation of PRMT7 related syndrome: Expanding the phenotypic manifestations

Roee Birnbaunn et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2019)

Article Biochemistry & Molecular Biology

Automethylation of protein arginine methyltransferase 7 and its impact on breast cancer progression

Pengyu Geng et al.

FASEB JOURNAL (2017)

Article Multidisciplinary Sciences

Epigenetic control via allosteric regulation of mammalian protein arginine methyltransferases

Kanishk Jain et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Biochemistry & Molecular Biology

Defining a Cancer Dependency Map

Aviad Tsherniak et al.

Article Biochemistry & Molecular Biology

Structural Insights into Ternary Complex Formation of Human CARM1 with Various Substrates

P. Ann Boriack-Sjodin et al.

ACS CHEMICAL BIOLOGY (2016)

Review Biochemistry & Molecular Biology

EMT: 2016

M. Angela Nieto et al.

Article Endocrinology & Metabolism

Prmt7 Deficiency Causes Reduced Skeletal Muscle Oxidative Metabolism and Age-Related Obesity

Hyeon-Ju Jeong et al.

DIABETES (2016)

Article Biochemistry & Molecular Biology

A feedback loop comprising PRMT7 and miR-24-2 interplays with Oct4, Nanog, Klf4 and c-Myc to regulate stemness

Sung-Hun Lee et al.

NUCLEIC ACIDS RESEARCH (2016)

Article Multidisciplinary Sciences

A glutamate/aspartate switch controls product specificity in a protein arginine methyltransferase

Erik W. Debler et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Cell Biology

PRMT7 Preserves Satellite Cell Regenerative Capacity

Romeo Sebastien Blanc et al.

CELL REPORTS (2016)

Article Multidisciplinary Sciences

Arginine methylation of HSP70 regulates retinoid acid-mediated RARβ2 gene activation

Wei-wei Gao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Chemistry, Medicinal

Discovery of a Dual PRMT5-PRMT7 Inhibitor

David Smil et al.

ACS MEDICINAL CHEMISTRY LETTERS (2015)

Article Biochemistry & Molecular Biology

Protein arginine methyltransferase 7 has a novel homodimer-like structure formed by tandem repeats

Morio Hasegawa et al.

FEBS LETTERS (2014)

Review Genetics & Heredity

A census of human RNA-binding proteins

Stefanie Gerstberger et al.

NATURE REVIEWS GENETICS (2014)

Article Biochemistry & Molecular Biology

Mammalian Protein Arginine Methyltransferase 7 (PRMT7) Specifically Targets RXR Sites in Lysine- and Arginine-rich Regions

You Feng et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Human Protein Arginine Methyltransferase 7 (PRMT7) Is a Type III Enzyme Forming ω-NG-Monomethylated Arginine Residues

Cecilia I. Zurita-Lopez et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance

Valentina Migliori et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)

Article Multidisciplinary Sciences

Dishevelled3 is a novel arginine methyl transferase substrate

Rama Kamesh Bikkavilli et al.

SCIENTIFIC REPORTS (2012)

Article Biochemistry & Molecular Biology

Methylation of eukaryotic elongation factor 2 induced by basic fibroblast growth factor via mitogen-activated protein kinase

Gyung Ah Jung et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2011)

Article Genetics & Heredity

Identification of genomic regions contributing to etoposide-induced cytotoxicity

Wasim K. Bleibel et al.

HUMAN GENETICS (2009)

Article Biochemistry & Molecular Biology

A Type III Protein Arginine Methyltransferase from the Protozoan Parasite Trypanosoma brucei

John C. Fisk et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Review Biochemistry & Molecular Biology

Protein Arginine Methylation in Mammals: Who, What, and Why

Mark T. Bedford et al.

MOLECULAR CELL (2009)

Article Biochemical Research Methods

Nuclear proteome analysis of undifferentiated mouse embryonic stem and germ cells

Nicolas Buhr et al.

ELECTROPHORESIS (2008)

Review Biochemistry & Molecular Biology

Translational control and the unfolded protein response

Ronald C. Wek et al.

ANTIOXIDANTS & REDOX SIGNALING (2007)

Article Cell Biology

Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins

Graydon B. Gonsalvez et al.

JOURNAL OF CELL BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Characterization of prmt7α and β isozymes from Chinese hamster cells sensitive and resistant to topoisomerase II inhibitors

Laurent Gros et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2006)

Review Biochemistry & Molecular Biology

Arginine methylation: An emerging regulator of protein function

MT Bedford et al.

MOLECULAR CELL (2005)

Review Biochemistry & Molecular Biology

Hsp70 chaperones: Cellular functions and molecular mechanism

MP Mayer et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2005)

Article Biochemistry & Molecular Biology

PRMT7, a new protein arginine methyltransferase that synthesizes symmetric dimethylarginine

JH Lee et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)