4.6 Article

Rutin Mediated Apoptotic Cell Death in Caski Cervical Cancer Cells via Notch-1 and Hes-1 Downregulation

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Rutin ameliorates copper sulfate-induced brain damage via antioxidative and anti-inflammatory activities in rats

Jeremiah Arowoogun et al.

Summary: The study demonstrated that rutin protected against copper-induced brain damage through antioxidative and anti-inflammatory mechanisms, improving body weight and oxidative stress and inflammatory responses in rat brain tissues.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2021)

Article Oncology

Jab1 Inhibition by Methanolic Extract ofMoringa OleiferaLeaves in Cervical Cancer Cells: A Potent Targeted Therapeutic Approach

Pratibha Pandey et al.

Summary: Research suggests that MMLE demonstrates inhibition against Jab1 in cervical cancer cells, leading to decreased cell growth, enhanced nuclear condensation, and down-regulation of Jab1 expression. Additionally, increased p27 expression and oxidative stress-induced caspase-3 activation are potential mechanisms behind the inhibitory effect of MMLE on Jab1.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2021)

Review Biotechnology & Applied Microbiology

Targeting Notch in oncology: the path forward

Samarpan Majumder et al.

Summary: The Notch pathway in cancer has multifaceted roles, acting as both an oncogene and a tumor suppressor depending on the context. Despite potential, developing safe and effective Notch-targeting agents for clinical use remains challenging.

NATURE REVIEWS DRUG DISCOVERY (2021)

Article Biochemistry & Molecular Biology

Elucidation of rutin's role in inducing caspase-dependent apoptosis via HPV-E6 and E7 down-regulation in cervical cancer HeLa cells

Pratibha Pandey et al.

Summary: Recent research has found that rutin exhibits inhibitory potential against several oncotargets in human cancer cells, particularly demonstrating effects on E6 and E7 oncoproteins in cervical cancer. By modulating cell cycle progression and altering protein expression levels, rutin induces apoptosis in HeLa cells and shows significant anti-tumor effects in both in vitro and in vivo experiments. Additionally, in silico studies support the findings by showing strong binding energy against selected target oncoproteins, suggesting rutin as a potential drug candidate for cervical cancer management.

BIOSCIENCE REPORTS (2021)

Article Biotechnology & Applied Microbiology

Notch pathway in ependymoma RELA-fused subgroup: upregulation and association with cancer stem cells markers expression

Taciani de Almeida Magalhaes et al.

CANCER GENE THERAPY (2020)

Article Endocrinology & Metabolism

Anti-Cancerous Effect of Rutin Against HPV C33A Cervical Cancer Cells via G0/G1 Cell Cycle Arrest and Apoptotic Induction

Fahad Khan et al.

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS (2020)

Review Chemistry, Applied

Flavonoids: biological activities and therapeutic potential

Mercia Marques Juca et al.

NATURAL PRODUCT RESEARCH (2020)

Article Biochemistry & Molecular Biology

Role of Rutin Nanoemulsion in Ameliorating Oxidative Stress: Pharmacokinetic and Pharmacodynamics Studies

Shrestha Sharma et al.

CHEMISTRY AND PHYSICS OF LIPIDS (2020)

Article Public, Environmental & Occupational Health

Global burden of cancer attributable to infections in 2018: a worldwide incidence analysis

Catherine de Martel et al.

LANCET GLOBAL HEALTH (2020)

Review Endocrinology & Metabolism

Molecular and Immunological Mechanisms Underlying Various Pharmacological Properties of the Potent Bioflavonoid, Rutin

David O. C. Yong et al.

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS (2020)

Review Biochemistry & Molecular Biology

Important Flavonoids and Their Role as a Therapeutic Agent

Asad Ullah et al.

MOLECULES (2020)

Article Oncology

Cancer Statistics, 2020: Report From National Cancer Registry Programme, India

Prashant Mathur et al.

JCO GLOBAL ONCOLOGY (2020)

Article Medicine, Research & Experimental

A novel rutin-fucoidan complex based phytotherapy for cervical cancer through achieving enhanced bioavailability and cancer cell apoptosis

Murugesan Sathiya Deepika et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Review Oncology

Notch signalling in cervical cancer

Calvin Rodrigues et al.

EXPERIMENTAL CELL RESEARCH (2019)

Article Pharmacology & Pharmacy

Rutin and orlistat produce antitumor effects via antioxidant and apoptotic actions

Amira Saleh et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2019)

Review Oncology

Drug resistance and combating drug resistance in cancer

Xuan Wang et al.

CANCER DRUG RESISTANCE (2019)

Review Oncology

Inhibiting CDK in Cancer Therapy: Current Evidence and Future Directions

Smruthi Vijayaraghavan et al.

TARGETED ONCOLOGY (2018)

Review Pharmacology & Pharmacy

Bioactive flavonoids in medicinal plants: Structure, activity and biological fate

Tian-yang Wang et al.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2018)

Review Biochemistry & Molecular Biology

Molecular Mechanisms and Pathways as Targets for Cancer Prevention and Progression with Dietary Compounds

Nagisa Nosrati et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Biochemistry & Molecular Biology

Understanding the Effectiveness of Natural Compound Mixtures in Cancer through Their Molecular Mode of Action

Thazin Nwe Aung et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Pharmacology & Pharmacy

The Pharmacological Potential of Rutin

Aditya Ganeshpurkar et al.

SAUDI PHARMACEUTICAL JOURNAL (2017)

Review Cell Biology

Mitochondria and Mitochondrial ROS in Cancer: Novel Targets for Anticancer Therapy

Yuhui Yang et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2016)

Review Biochemistry & Molecular Biology

Cell death mechanisms of plant-derived anticancer drugs: beyond apoptosis

Hala Gali-Muhtasib et al.

APOPTOSIS (2015)

Article Biochemistry & Molecular Biology

MiR-139-5p inhibits the biological function of breast cancer cells by targeting Notch1 and mediates chemosensitivity to docetaxel

He-da Zhang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Review Biochemistry & Molecular Biology

Targeting Apoptosis and Multiple Signaling Pathways with Icariside II in Cancer Cells

Muhammad Khan et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2015)

Editorial Material Gastroenterology & Hepatology

Notch-driven carcinogenesis: The merging of hepatocellular cancer and cholangiocarcinoma into a common molecular liver cancer subtypes

Nataliya Razumilava et al.

JOURNAL OF HEPATOLOGY (2013)

Review Oncology

Mitochondria and cancer

Douglas C. Wallace

NATURE REVIEWS CANCER (2012)

Review Oncology

Targeting Cell Signaling and Apoptotic Pathways by Dietary Agents: Role in the Prevention and Treatment of Cancer

Muthu K. Shanmugam et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2011)

Review Pharmacology & Pharmacy

Plant-derived compounds in clinical trials

Arvind Saklani et al.

DRUG DISCOVERY TODAY (2008)

Review Biochemistry & Molecular Biology

Cyclins and cdks in development and cancer: a perspective

A Deshpande et al.

ONCOGENE (2005)

Review Chemistry, Medicinal

Radioprotection by plant products: Present status and future prospects

R Arora et al.

PHYTOTHERAPY RESEARCH (2005)

Article Oncology

Radioprotectants: Current status and new directions

DJ Grdina et al.

ONCOLOGY (2002)

Article Multidisciplinary Sciences

Proliferation, cell cycle and apoptosis in cancer

GI Evan et al.

NATURE (2001)