Journal
MEMBRANES
Volume 11, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/membranes11060403
Keywords
nicotine; tobacco; extraction; fast dissolving formulation; thin film
Categories
Funding
- Faculty of Pharmacy
- Chiang Mai University
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The study found that nicotine extracted from the upper part of tobacco leaves using acid-base extraction method had the highest content, and the fast dissolving film formulation showed rapid and effective nicotine release.
Nicotine (NCT), administered in the form of a fast dissolving oral delivery system, can be a potential alternative to nicotine replacement therapy. NCT was extracted by maceration and acid-base extraction methods from Burley tobacco leaves with different stalk positions and extraction yield and NCT content were further determined. The extract with the highest nicotine content was selected for incorporation into a fast dissolving film formulation. The optimized film was evaluated for its physical and mechanical properties, in vitro disintegration, and drug release profile. The results demonstrated that the extract from the upper part of tobacco leaves using the acid-base extraction method had the highest amount of NCT. NCT fast dissolving film consisting of this extract as the active ingredient and HPMC E15 as a film polymer resulted in a homogeneous translucent film with a light brown color. The addition of NCT significantly affected the film properties in terms of weight, disintegration time, tensile strength, percentage elongation at break, and Young's modulus values. The drug release of NCT fast dissolving film showed a rapid initial release of 80% within three minutes, and its kinetics followed the Higuchi matrix model. The results suggest that these NCT films can be employed in the development of NCT fast dissolving films for clinical use.
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