Surface Acoustic Wave Biosensor with Laser-Deposited Gold Layer Having Controlled Porosity

Laser-deposited gold immobilization layers having different porosities were incorporated into love wave surface acoustic wave sensors (LW-SAWs). Variation of pulsed laser deposition parameters allows good control of the gold film morphology. Biosensors with various gold film porosities were tested using the biotin-avidin reaction. Control of the Au layer morphology is important since the biotin and avidin layer morphologies closely follow that of the gold. The response of the sensors to biotin/avidin, which is a good indicator of biosensor performance, is improved when the gold layer has increased porosity. Given the sizes of the proteins, the laser-deposited porous gold interfaces have optimal pore dimensions to ensure protein stability.

Automated summary

Laser-deposited gold immobilization layers with different porosities were incorporated into Love Wave surface acoustic wave sensors. Control of the gold layer morphology is crucial for biosensor performance improvement, especially when it comes to the biotin-avidin reaction. The porous gold interfaces deposited by laser have optimal pore dimensions to ensure protein stability, leading to enhanced biosensor response to biotin-avidin.