Journal
CHEMOSENSORS
Volume 9, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/chemosensors9080205
Keywords
prostate cancer; biosensors; biomarkers; glycans; lectins; aptamers; molecularly imprinted polymers
Funding
- Slovak Research and Development Agency [APVV 20-0476]
- Ministry of Health of the Slovak Republic [2019/68-CHuSAV-1]
- Qatar University and Chemical Institute, Slovak Academy of Sciences [IRCC-2020-004]
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The review gives an overview of prostate cancer (PCa) incidence, mortality, and diagnostic methods, highlighting the need for novel biomarkers. In addition to prostate specific antigen, the review discusses alternative biomarkers available for PCa diagnostics, including low and high molecular mass biomolecules.
The review initially provides a short introduction to prostate cancer (PCa) incidence, mortality, and diagnostics. Next, the need for novel biomarkers for PCa diagnostics is briefly discussed. The core of the review provides details about PCa aetiology, alternative biomarkers available for PCa diagnostics besides prostate specific antigen and their biosensing. In particular, low molecular mass biomolecules (ions and metabolites) and high molecular mass biomolecules (proteins, RNA, DNA, glycoproteins, enzymes) are discussed, along with clinical performance parameters.
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