Journal
BIOSENSORS-BASEL
Volume 11, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/bios11080246
Keywords
peptide; electrochemical biosensor; antifouling; protease; biomarker; bioreceptor
Funding
- Regione Toscana Bando Salute 2018 [D78D20000870002]
- Fondazione CR [2018.0944, 2020.1662]
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Peptides, as a promising class of biorecognition elements, play a significant role in the design and development of electrochemical biosensors. They offer benefits such as stability and selectivity, and can be easily synthesized and modified for use in novel biosensing platforms.
Peptides represent a promising class of biorecognition elements that can be coupled to electrochemical transducers. The benefits lie mainly in their stability and selectivity toward a target analyte. Furthermore, they can be synthesized rather easily and modified with specific functional groups, thus making them suitable for the development of novel architectures for biosensing platforms, as well as alternative labelling tools. Peptides have also been proposed as antibiofouling agents. Indeed, biofouling caused by the accumulation of biomolecules on electrode surfaces is one of the major issues and challenges to be addressed in the practical application of electrochemical biosensors. In this review, we summarise trends from the last three years in the design and development of electrochemical biosensors using synthetic peptides. The different roles of peptides in the design of electrochemical biosensors are described. The main procedures of selection and synthesis are discussed. Selected applications in clinical diagnostics are also described.
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