Journal
FRONTIERS IN NUTRITION
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnut.2021.687133
Keywords
iron supplement; peptides-ferrous chelate; oat peptide; iron-deficient anemic; antioxidant activity
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Funding
- National High Technology Research and Development Program 863 [2013AA102203]
- Jiangsu University Foundation of China [07JDG016]
- Key Technology R&D Program of Zhenjiang [SH2019011]
- Laboratory Animal Association Foundation of Jiangsu [DWXH201910]
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Iron-chelating peptides are widely recognized as effective iron supplements for alleviating iron deficiency. In this study, a novel oat peptides-ferrous chelate was prepared with high chelating rate and antioxidant activity. Results showed that the OP-Fe2+ chelate improved anemia and enhanced antioxidant activities in IDA rats.
Iron-chelating peptides have been widely considered as one of the best iron supplements to alleviate the iron deficiency. In this study, a novel oat peptides-ferrous (OP-Fe2+) chelate was prepared from antioxidant oat peptides obtained in the laboratory of the authors. The optimal preparation condition was obtained through the single-factor and response surface methodology, and the chelating rate could reach up to 62.6%. After chelation, the OP-Fe2+ chelate exhibited a significantly higher 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity than oat peptides. It was discovered that the hemoglobin concentration and the number of red blood cell levels in OP-Fe2+-treated iron-deficient anemic (IDA) rats were significantly higher than untreated IDA rats. The OP-Fe2+ chelate could also improve the hypertrophy of the spleen, serum iron (SI), total iron and binding capacity, and serum ferritin levels in the IDA rats. In addition, the OP-Fe2+ treatment significantly increased the antioxidant activities of super oxidase and glutathione in the liver homogenate of the IDA rats. Therefore, the OP-Fe2+ chelate is an effective type of iron supplement for IDA rats, which could be a promising source with anti-anemia and antioxidant activity.
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