Journal
BIOLOGY-BASEL
Volume 10, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/biology10080783
Keywords
alpha CGRP; carbohydrate oxidation; power; cardiorespiratory fitness; VO2max
Categories
Funding
- Fundacion Bancaja-UMH - Universidad Miguel Hernandez de Elche
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The study found that the majority of young men respond to a single maximal exercise bout with an increase in blood alpha-CGRP concentration, and this response is associated with their cardiorespiratory fitness, carbohydrate oxidation, and work performed.
This study aimed to explore if the acute variations in plasma concentration of alpha-calcitonin gene-related peptide (alpha CGRP) induced by a single maximal exercise bout may be associated to cardiorespiratory fitness and carbohydrate oxidation in humans. Twelve young adult Caucasian men (24.3 +/- 0.9 years-old; 179.2 +/- 1.9 cm of height; 23.9 +/- 0.6 kg.m(-2) body mass index) performed a graded exercise test. A venous catheter was placed before testing, and blood samples were taken at baseline, maximal effort and recovery. alpha CGRP was measured in plasma using a commercial double-sandwich enzyme-linked-immunoassay. A two-way repeated measurements ANOVA was used to compare the values obtained at baseline, maximal effort and recovery. In the whole sample, alpha CGRP increased at maximal effort and its concentration correlated directly, albeit non-significantly, with the muscle mass normalised VO2, VCO2, carbohydrate oxidation and relative power. Two thirds of the participants showed an increase in alpha CGRP concentration at maximal effort. Post hoc analysis showed that in these individuals, the muscle mass normalised VO2, VCO2, carbohydrate oxidation rate and relative power were higher than in the participants lacking this molecular response. Therefore, our data suggest that (a) a majority of young men respond to exercise with an increase in blood alpha CGRP concentration; and (b) individuals exhibiting this response also show a higher cardiorespiratory fitness, carbohydrate oxidation and work performed. These findings suggest that this neuropeptide could act as an exerkine with potential effects on physical performance.
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