Journal
GREEN CHEMISTRY
Volume 18, Issue 8, Pages 2507-2513Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5gc02583d
Keywords
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Funding
- National Natural Science Foundation of China [21273044, 21473035, 91545108]
- Research Fund for the Doctoral Program of Higher Education [2012007000011]
- Science & Technology Commission of Shanghai Municipality [08DZ2270-500, 12ZR1401500]
- SINOPEC [X514005]
- Hui-Chun Chin and Tsung-Dao Lee Chinese Undergraduate Research Endowment (CURE) [13036]
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Reductive amination (RA) is one of the most important transformations in organic chemistry. A versatile and sustainable gas-free RA of aldehydes carried out directly with cheaply available nitroarenes using stoichiometric amounts of non-toxic and entirely renewable formic acid (FA) as the terminal reductant is described herein. A single phase rutile titania supported gold (Au/TiO2-R) catalyst is shown to catalyse efficiently this FA-based direct RA in neat water under mild reaction conditions. The broad scope, mild and neutral conditions, together with CO2 and water as environmental harmless byproducts, make this transformation very useful. Moreover, straightforward examples of the direct construction of bioactive heterocyclic compounds containing a benzimidazole motif were achieved through this protocol.
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