4.6 Review

The Link Between Ferroptosis and Cardiovascular Diseases: A Novel Target for Treatment

Related references

Note: Only part of the references are listed.
Article Cell Biology

Human umbilical cord blood-derived MSCs exosome attenuate myocardial injury by inhibiting ferroptosis in acute myocardial infarction mice

Yufang Song et al.

Summary: This study found that exosomes derived from human umbilical cord blood-derived MSCs (HUCB-MSC) inhibit ferroptosis by regulating DMT1 expression through miR-23a-3p, reducing myocardial injury.

CELL BIOLOGY AND TOXICOLOGY (2021)

Article Pharmacology & Pharmacy

Ferroptosis occurs in phase of reperfusion but not ischemia in rat heart following ischemia or ischemia/reperfusion

Li-Jing Tang et al.

Summary: The study evaluated the contribution of ferroptosis to myocardial ischemia or reperfusion injury, finding that ferroptosis mainly occurs during myocardial reperfusion. The use of iron chelator deferoxamine attenuated reperfusion injury but had no significant effect on ischemic injury.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2021)

Review Cardiac & Cardiovascular Systems

Heart failure after myocardial infarction: incidence and predictors

Dominik Jenca et al.

Summary: Heart failure remains a common complication of myocardial infarction. Timely identification of at-risk individuals and early initiation of guideline-directed therapy can reduce the burden of heart failure.

ESC HEART FAILURE (2021)

Article Endocrinology & Metabolism

Role of ferroptosis in the process of diabetes-induced endothelial dysfunction

Er-Fei Luo et al.

Summary: Ferroptosis is involved in endothelial dysfunction caused by diabetes, with activation of the p53-xCT-GSH axis playing a crucial role in endothelial cell ferroptosis and dysfunction.

WORLD JOURNAL OF DIABETES (2021)

Article Cardiac & Cardiovascular Systems

Oxidized phosphatidylcholines trigger ferroptosis in cardiomyocytes during ischemia-reperfusion injury

Aleksandra Stamenkovic et al.

Summary: Oxidized phosphatidylcholines (OxPC) generated during reperfusion injury induce cardiomyocyte death through ferroptosis, which can be attenuated by neutralization of OxPC or with ferrostatin-1. Understanding this pathway may lead to novel strategies for preventing cell death during myocardial reperfusion injury.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2021)

Article Biochemistry & Molecular Biology

ELAVL1 is transcriptionally activated by FOXC1 and promotes ferroptosis in myocardial ischemia/reperfusion injury by regulating autophagy

Hui-Yong Chen et al.

Summary: Myocardial ischemia is a common cardiovascular disease that can lead to significant morbidity and mortality. This study aimed to investigate the role of ELAVL1 in regulating myocardial ischemia and reperfusion injury, and found that ELAVL1 may promote ferroptosis through modulating autophagy, leading to myocardial injury. Inhibition of ELAVL1-mediated autophagic ferroptosis could be a potential new treatment strategy for myocardial I/R injury.

MOLECULAR MEDICINE (2021)

Article Cell Biology

PDK4 dictates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acid synthesis

Xinxin Song et al.

Summary: Glucose determines the sensitivity of human pancreatic ductal carcinoma cells to ferroptosis and PDK4 is identified as the top gene responsible for ferroptosis resistance. Inhibiting PDK4 enhances the anticancer activity of system xc(-) inhibitors in vitro and in suitable preclinical mouse models. These findings suggest metabolic reprogramming as a potential target for overcoming ferroptosis resistance.

CELL REPORTS (2021)

Article Cell Biology

Ferritinophagy is involved in the zinc oxide nanoparticles-induced ferroptosis of vascular endothelial cells

Xia Qin et al.

Summary: Zinc oxide nanoparticles can induce ferroptosis in endothelial cells, characterized by increased intracellular iron levels, lipid peroxidation, and cell death. NCOA4-mediated ferritinophagy plays a crucial role in ZnONPs-induced ferroptosis.

AUTOPHAGY (2021)

Review Medicine, Research & Experimental

The role of iron in the pathogenesis of COVID-19 and possible treatment with lactoferrin and other iron chelators

Hosam M. Habib et al.

Summary: Iron overload is increasingly seen as a contributor to the pathogenesis of COVID-19, triggering inflammation, hypercoagulation, hyperferritinemia, and immune dysfunction. Iron chelators, including the naturally occurring lactoferrin, may hold therapeutic value in COVID-19 by modulating the immune response and blocking the entry of coronaviruses into host cells.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Biochemistry & Molecular Biology

Tumor resistance to ferroptosis driven by Stearoyl-CoA Desaturase-1 (SCD1) in cancer cells and Fatty Acid Biding Protein-4 (FABP4) in tumor microenvironment promote tumor recurrence

Geraldine Luis et al.

Summary: The study revealed that SCD1 and FABP4 play essential roles in tumor recurrence by enhancing antioxidant and anti-ferroptotic resources. Inhibiting lipid transport and targeting SCD1 can effectively reduce tumor regrowth.

REDOX BIOLOGY (2021)

Article Multidisciplinary Sciences

Apoferritin improves motor deficits in MPTP-treated mice by regulating brain iron metabolism and ferroptosis

Li-Mei Song et al.

Summary: The study found that apoferritin has a neuroprotective effect against MPTP-induced PD by inhibiting iron aggregation and modulating ferroptosis, providing a promising therapeutic target for the treatment of PD.

ISCIENCE (2021)

Article Cardiac & Cardiovascular Systems

circSnx12 Is Involved in Ferroptosis During Heart Failure by Targeting miR-224-5p

Haoyuan Zheng et al.

Summary: This study investigated the regulatory mechanism of circRNA and iron metabolism in heart failure, identifying genes related to iron metabolism and constructing a circRNA-miRNA-mRNA regulatory network. Experimental validations in heart failure mice confirmed the predicted effects on FTH1 expression, as well as the presence of fibrosis and elevated levels of iron and MDA in myocardial tissues. The findings suggest potential circRNA targets for heart failure treatment.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

Article Biochemistry & Molecular Biology

Verification of ferroptosis and pyroptosis and identification of PTGS2 as the hub gene in human coronary artery atherosclerosis

Yaqing Zhou et al.

Summary: The study found that proteins closely related to the severity of atherosclerosis, such as PTGS2, ACSL4, caspase-1, and NLRP3, may be associated with ferroptosis and pyroptosis, and involved in the occurrence and development of atherosclerosis. These proteins interact with each other, and PTGS2 may be the central gene in this process.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Article Cell Biology

CIRBP promotes ferroptosis by interacting with ELAVL1 and activating ferritinophagy during renal ischaemia-reperfusion injury

Mingxing Sui et al.

Summary: Experimental results indicate an interaction between CIRBP and ELVAL1, with ELVAL1 playing a critical role in promoting ferritinophagy activation and ferroptosis. In the context of renal ischaemia-reperfusion injury, CIRBP-enhanced ferritinophagy-mediated ferroptosis could serve as a significant factor.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Article Biochemistry & Molecular Biology

ESCRT-III-dependent membrane repair blocks ferroptosis

Enyong Dai et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

Ferroptosis Is Involved in Diabetes Myocardial Ischemia/Reperfusion Injury Through Endoplasmic Reticulum Stress

Wenyuan Li et al.

DNA AND CELL BIOLOGY (2020)

Article Cell Biology

Energy-stress-mediated AMPK activation inhibits ferroptosis

Hyemin Lee et al.

NATURE CELL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis

Yilong Zou et al.

NATURE CHEMICAL BIOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Action of iron chelator on intramyocardial hemorrhage and cardiac remodeling following acute myocardial infarction

Bita Behrouzi et al.

BASIC RESEARCH IN CARDIOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis

Xuexian Fang et al.

CIRCULATION RESEARCH (2020)

Review Pharmacology & Pharmacy

Distinct Types of Cell Death and the Implication in Diabetic Cardiomyopathy

Yun Chen et al.

FRONTIERS IN PHARMACOLOGY (2020)

Article Chemistry, Multidisciplinary

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

Vanessa A. N. Kraft et al.

ACS CENTRAL SCIENCE (2020)

Article Medicine, Research & Experimental

Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity

Tomonori Tadokoro et al.

JCI INSIGHT (2020)

Article Biochemistry & Molecular Biology

NEDD4L-mediated LTF protein degradation limits ferroptosis

Yuan Wang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Review Cell Biology

Iron Metabolism in Ferroptosis

Xin Chen et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Fatal lymphocytic cardiac damage in coronavirus disease 2019 (COVID-19): autopsy reveals a ferroptosis signature

Werner Jacobs et al.

ESC HEART FAILURE (2020)

Article Biochemistry & Molecular Biology

Ferritinophagy-mediated ferroptosis is involved in sepsis-induced cardiac injury

Ning Li et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

Review Chemistry, Multidisciplinary

Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy

Maura Knapp et al.

ACTA PHARMACOLOGICA SINICA (2019)

Article Multidisciplinary Sciences

Ferroptosis as a target for protection against cardiomyopathy

Xuexian Fang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Cardiac & Cardiovascular Systems

Diabetic cardiomyopathy - A comprehensive updated review

Ghulam Murtaza et al.

PROGRESS IN CARDIOVASCULAR DISEASES (2019)

Review Cardiac & Cardiovascular Systems

Current Status and Challenges of NRF2 as a Potential Therapeutic Target for Diabetic Cardiomyopathy

Zhi-Dong Ge et al.

INTERNATIONAL HEART JOURNAL (2019)

Article Medicine, Research & Experimental

Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation

Wenjun Li et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Article Biochemistry & Molecular Biology

Role of TLR4/NADPH oxidase 4 pathway in promoting cell death through autophagy and ferroptosis during heart failure

Xiaoqing Chen et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Review Physiology

FUNDAMENTAL MECHANISMS OF REGULATED CELL DEATH AND IMPLICATIONS FOR HEART DISEASE

Dominic P. Del Re et al.

PHYSIOLOGICAL REVIEWS (2019)

Article Cell Biology

The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma

Wen-Hsuan Yang et al.

CELL REPORTS (2019)

Article Multidisciplinary Sciences

FSP1 is a glutathione-independent ferroptosis suppressor

Sebastian Doll et al.

NATURE (2019)

Article Multidisciplinary Sciences

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

Kirill Bersuker et al.

NATURE (2019)

Article Biochemistry & Molecular Biology

Liproxstatin-1 protects the mouse myocardium against ischemia/reperfusion injury by decreasing VDAC1 levels and restoring GPX4 levels

Yansheng Feng et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Article Cell Biology

Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export

Caitlin W. Brown et al.

DEVELOPMENTAL CELL (2019)

Article Biochemistry & Molecular Biology

Role of Mitochondria in Ferroptosis

Minghui Gao et al.

MOLECULAR CELL (2019)

Review Biochemistry & Molecular Biology

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

Matthew Dodson et al.

REDOX BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Determination of the Subcellular Localization and Mechanism of Action of Ferrostatins in Suppressing Ferroptosis

Michael M. Gaschler et al.

ACS CHEMICAL BIOLOGY (2018)

Article Cardiac & Cardiovascular Systems

Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes

Yuichi Baba et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2018)

Article Biochemistry & Molecular Biology

Puerarin protects against heart failure induced by pressure overload through mitigation of ferroptosis

Bei Liu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Review Biochemistry & Molecular Biology

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Lorenzo Galluzzi et al.

CELL DEATH AND DIFFERENTIATION (2018)

Review Cardiac & Cardiovascular Systems

Diabetic Cardiomyopathy: An Update of Mechanisms Contributing to This Clinical Entity

Guanghong Jia et al.

CIRCULATION RESEARCH (2018)

Article Biochemistry & Molecular Biology

Mitochondrial rescue prevents glutathione peroxidase-dependent ferroptosis

Anja Jelinek et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

Article Biochemistry & Molecular Biology

Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis

Shashank Masaldan et al.

REDOX BIOLOGY (2018)

Review Cell Biology

Ferritinophagy/ferroptosis: Iron-related newcomers in human diseases

Mingzhu Tang et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

Article Cardiac & Cardiovascular Systems

Fourth Universal Definition of Myocardial Infarction (2018)

Kristian Thygesen et al.

CIRCULATION (2018)

Article Physiology

Heme oxygenase-1 mitigates ferroptosis in renal proximal tubule cells

Oreoluwa Adedoyin et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2018)

Article Biochemistry & Molecular Biology

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Valerian E. Kagan et al.

NATURE CHEMICAL BIOLOGY (2017)

Article Biochemistry & Molecular Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Sebastian Doll et al.

NATURE CHEMICAL BIOLOGY (2017)

Review Cardiac & Cardiovascular Systems

Impact of Oxidative Stress on the Heart and Vasculature Part 2 of a 3-Part Series

Thomas Muenzel et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2017)

Article Multidisciplinary Sciences

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

Samantha W. Alvarez et al.

NATURE (2017)

Article Multidisciplinary Sciences

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

Vasanthi S. Viswanathan et al.

NATURE (2017)

Article Biochemistry & Molecular Biology

BID links ferroptosis to mitochondrial cell death pathways

Sandra Neitemeier et al.

REDOX BIOLOGY (2017)

Article Cell Biology

Autophagy promotes ferroptosis by degradation of ferritin

Wen Hou et al.

AUTOPHAGY (2016)

Article Biochemistry & Molecular Biology

CISD1 inhibits ferroptosis by protection against mitochondrial lipid peroxidation

Hua Yuan et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

Article Cell Biology

Ferroptosis is an autophagic cell death process

Minghui Gao et al.

CELL RESEARCH (2016)

Review Cardiac & Cardiovascular Systems

2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

Piotr Ponikowski et al.

EUROPEAN HEART JOURNAL (2016)

Article Biochemistry & Molecular Biology

Therapeutic inhibition of mitochondrial reactive oxygen species with mito-TEMPO reduces diabetic cardiomyopathy

Rui Ni et al.

FREE RADICAL BIOLOGY AND MEDICINE (2016)

Article Multidisciplinary Sciences

Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses

Yang Ou et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Multidisciplinary Sciences

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

Wan Seok Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Biochemistry & Molecular Biology

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

Scott J. Dixon et al.

ACS CHEMICAL BIOLOGY (2015)

Article Immunology

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection

Mai Matsushita et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2015)

Article Biochemistry & Molecular Biology

Glutaminolysis and Transferrin Regulate Ferroptosis

Minghui Gao et al.

MOLECULAR CELL (2015)

Article Multidisciplinary Sciences

Ferroptosis as a p53-mediated activity during tumour suppression

Le Jiang et al.

NATURE (2015)

Article Biochemistry & Molecular Biology

HSPB1 as a novel regulator of ferroptotic cancer cell death

X. Sun et al.

ONCOGENE (2015)

Article Biochemistry & Molecular Biology

Regulation of Ferroptotic Cancer Cell Death by GPX4

Wan Seok Yang et al.

Article Multidisciplinary Sciences

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

Joseph D. Mancias et al.

NATURE (2014)

Article Cell Biology

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Jose Pedro Friedmann Angeli et al.

NATURE CELL BIOLOGY (2014)

Review Cell Biology

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

Tom Vanden Berghe et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

Review Physiology

SYSTEMIC IRON HOMEOSTASIS

Tomas Ganz

PHYSIOLOGICAL REVIEWS (2013)

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

Review Biochemistry & Molecular Biology

Ischemia and reperfusion-from mechanism to translation

Holger K. Eltzschig et al.

NATURE MEDICINE (2011)

Article Biochemistry & Molecular Biology

Suppression of atherogenesis by overexpression of glutathione peroxidase-4 in apolipoprotein E-deficient mice

ZhongMao Guo et al.

FREE RADICAL BIOLOGY AND MEDICINE (2008)

Article Biochemistry & Molecular Biology

Heat shock protein 27 downregulates the transferrin receptor 1-mediated iron uptake

Huaiyong Chen et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2006)

Letter Biochemistry & Molecular Biology

Pro-inflammatory programmed cell death

BT Cookson et al.

TRENDS IN MICROBIOLOGY (2001)