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Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition -: The role of HIF-1α, HIF-2α, and other pathways
Gareth P. Elvidge et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
A constitutively active hypoxia-inducible factor-1α/VP16 hybrid factor activates expression of the human B-type natriuretic peptide gene
Yuxia Luo et al.
MOLECULAR PHARMACOLOGY (2006)
Stabilization of hypoxia inducible factor rather than modulation of collagen metabolism improves cardiac function after acute myocardial infarction in rats
Sebastian Philipp et al.
EUROPEAN JOURNAL OF HEART FAILURE (2006)
The allosteric properties of hemoglobin: Insights from natural and site directed mutants
A Bellelli et al.
CURRENT PROTEIN & PEPTIDE SCIENCE (2006)
Improvement of myocardial perfusion in coronary patients after intermittent hypobaric hypoxia
MD Valle et al.
JOURNAL OF NUCLEAR CARDIOLOGY (2006)
Hypoxia-inducible factor prolyl 4-hydroxylase inhibition - A target for neuroprotection in the central nervous system
A Siddiq et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Hypoxia-inducible factor 1-alpha reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse
M Kido et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2005)
Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene
N Pescador et al.
BIOCHEMICAL JOURNAL (2005)
Hypoxia-inducible factor 1α polymorphism and coronary collaterals in patients with ischemic heart disease
JR Resar et al.
CHEST (2005)
Influence of ventricular pacing on myocardial oxygen tension
K Matschke et al.
MICROVASCULAR RESEARCH (2005)
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
RD Guzy et al.
CELL METABOLISM (2005)
Age-dependent increase of prolyl-4-hydroxylase domain (PHD) 3 expression in human and mouse heart
S Rohrbach et al.
BIOGERONTOLOGY (2005)
Brain-specific knock-out of hypoxia-inducible factor-1α reduces rather than increases hypoxic-ischemic damage
R Helton et al.
JOURNAL OF NEUROSCIENCE (2005)
Myocardial ischemia/reperfusion-injury, a clinical view on a complex pathophysiological process
AL Moens et al.
INTERNATIONAL JOURNAL OF CARDIOLOGY (2005)
Human HIF-3 alpha 4 is a dominant-negative regulator of HIF-1 and is down-regulated in renal cell carcinoma
MA Maynard et al.
FASEB JOURNAL (2005)
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase
MA Selak et al.
CANCER CELL (2005)
The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease
DIR Holmes et al.
GENOME BIOLOGY (2005)
Cardiac myocyte-specific HIF-1α deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart
Y Huang et al.
FASEB JOURNAL (2004)
The structure-function relationship of hemoglobin in solution at atomic resolution
JA Lukin et al.
CHEMICAL REVIEWS (2004)
Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor
RJ Appelhoff et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Cellular and molecular pathobiology of pulmonary arterial hypertension
M Humbert et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2004)
Respiratory metabolism: glycolysis, the TCA cycle and mitochondrial electron transport
AR Fernie et al.
CURRENT OPINION IN PLANT BIOLOGY (2004)
Oxygen sensing by HIF hydroxylases
CJ Schofield et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2004)
Differential roles of hypoxia-inducible factor 1α (HIF-1α) and HIF-2α in hypoxic gene regulation
CJ Hu et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Mitochondrial formation of reactive oxygen species
JF Turrens
JOURNAL OF PHYSIOLOGY-LONDON (2003)
Production of reactive oxygen species by mitochondria - Central role of complex III
Q Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1α in normoxia
E Berra et al.
EMBO JOURNAL (2003)
Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury
ZQ Cai et al.
CIRCULATION (2003)
Intrauterine growth restriction, preeclampsia, and intrauterine mortality at high altitude in Bolivia
LE Keyes et al.
PEDIATRIC RESEARCH (2003)
The first direct characterization of a high-valent iron intermediate in the reaction of an α-ketoglutarate-dependent dioxygenase:: A high-spin Fe(IV) complex in taurine/α-ketoglutarate dioxygenase (TauD) from Escherichia coli
JC Price et al.
BIOCHEMISTRY (2003)
Differential regulation of HIF-1α prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells
CL Cioffi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Widespread, hypoxia-inducible expression of HIF-2α in distinct cell populations of different organs
MS Wiesener et al.
FASEB JOURNAL (2002)
Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia
SO Ang et al.
NATURE GENETICS (2002)
Endothelial PAS domain protein 1 (EPAS1) induces adrenomedullin gene expression in cardiac myocytes: Role of EPAS1 in an inflammatory response in cardiac myocytes
T Tanaka et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2002)
Structural basis for Hif-1α/CBP recognition in the cellular hypoxic response
SA Dames et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Early expression of myocardial HIF-1α in response to mechanical stresses -: Regulation by stretch-activated channels and the phosphatidylinositol 3-kinase signaling pathway
CH Kim et al.
CIRCULATION RESEARCH (2002)
Global burden of cardiovascular diseases - Part I: General considerations, the epidemiologic transition, risk factors, and impact of urbanization
S Yusuf et al.
CIRCULATION (2001)
Big endothelin-1 and endothelin-1 plasma levels are correlated with the severity of primary pulmonary hypertension
C Rubens et al.
CHEST (2001)
Expression and characterization of hypoxia-inducible factor (HIF)-3α in human kidney:: Suppression of HIF-mediated gene expression by HIF-3α
S Hara et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)
Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis
RM Tuder et al.
JOURNAL OF PATHOLOGY (2001)
Physiological and genomic consequences of intermittent hypoxia -: Invited review:: Oxygen sensing during intermittent hypoxia:: cellular and molecular mechanisms
NR Prabhakar
JOURNAL OF APPLIED PHYSIOLOGY (2001)
Responses of single-unit carotid body chemoreceptors in adult rats
EH Vidruk et al.
JOURNAL OF PHYSIOLOGY-LONDON (2001)
Sleep-disordered breathing and cardiovascular disease: Cross-sectional results of the sleep heart health study
E Shahar et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2001)
Age-dependent defect in vascular endothelial growth factor expression is associated with reduced hypoxia-inducible factor 1 activity
A Rivard et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
ME Cockman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages
KL Talks et al.
AMERICAN JOURNAL OF PATHOLOGY (2000)
Intravenous nesiritide, a natriuretic peptide, in the treatment of decompensated congestive heart failure.
WS Colucci et al.
NEW ENGLAND JOURNAL OF MEDICINE (2000)
Plasma adrenomedullin, a new independent predictor of prognosis in patients with chronic heart failure
F Pousset et al.
EUROPEAN HEART JOURNAL (2000)
Prospective study of the association between sleep-disordered breathing and hypertension
PE Peppard et al.
NEW ENGLAND JOURNAL OF MEDICINE (2000)
Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study
FJ Nieto et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2000)
Tissue hypoxygenation activates the adrenomedullin system in vivo
KH Hofbauer et al.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2000)