Characterization of nanoparticles combining polyamine detection with photodynamic therapy

Polyamine detection and depletion have been extensively investigated for cancer prevention and treatment. However, the therapeutic efficacy is far from satisfactory, mainly due to a polyamine compensation mechanism from the systemic circulation in the tumor environment. Herein, we explore a new solution for improving polyamine detection as well as a possible consumption therapy based on a new photosensitizer that can efficiently consume polyamines via an irreversible chemical reaction. The new photosensitizer is pyrrolopyrroleaza-BODIPY pyridinium salt (PPAB-PyS) nanoparticles that can react with the over-expressed polyamine in cancer cells and produce two photosensitizers with enhanced phototoxicity on cancer destruction. Meanwhile, PPAB-PyS nanoparticles provide a simultaneous ratiometric fluorescence imaging of intracellular polyamine. This combination polyamine consumption with a chemical reaction provides a new modality to enable polyamine detection along with photodynamic therapy as well as a putative depletion of polyamines for cancer treatment and prevention. Li et al develop PPAB-PyS nanoparticles that simultaneously allows intracellular imaging and ratiometric detection of the intracellular polyamine. With an additional potential to consume polyamines via an irreversible chemical reaction, the authors thus provide an alternative approach for photodynamic therapy with polyamine detection.

Automated summary

The research developed a new photosensitizer nanoparticle that can react with over-expressed polyamines in cancer cells, producing two photosensitizers with enhanced phototoxicity. Simultaneously, the nanoparticles provide ratiometric fluorescence imaging of intracellular polyamines. This combination of polyamine consumption with a chemical reaction offers a new approach for polyamine detection and photodynamic therapy, potentially leading to depletion of polyamines for cancer treatment and prevention.