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Article
Oncology
A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage
Xueqing Zou et al.
Summary: The study investigates the impact of knockout of 42 human DNA repair genes on mutational patterns using CRISPR-Cas9 and whole-genome sequencing. A clinically relevant tool to detect mismatch repair-deficient tumors was developed and validated for enhanced detection of MMR-deficient tumors with implications for immunotherapy responsiveness.
NATURE CANCER (2021)
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