4.6 Article

Antiparasitic Properties of Cardiovascular Agents against Human Intravascular Parasite Schistosoma mansoni

Related references

Note: Only part of the references are listed.
Editorial Material Chemistry, Medicinal

Alternatives to Praziquantel for the Prevention and Control of Schistosomiasis

Thomas Spangenberg

Summary: Schistosomiasis, a neglected tropical disease caused by infection with parasitic blood flukes, affects millions worldwide with limited treatment options. The World Health Organization calls for the development of new drugs to eliminate this public health problem.

ACS INFECTIOUS DISEASES (2021)

Article Parasitology

Antischistosomal properties of aurone derivatives against juvenile and adult worms of Schistosoma mansoni

Vinicius R. D. Pereira et al.

Summary: Aurone derivatives have shown potential as effective agents against Schistosoma mansoni, displaying concentration-dependent tegumental damage on parasites with no cytotoxic or haemolytic effects on mammalian cells. In a mouse model of schistosomiasis, the aurones demonstrated significant reductions in worm burden and egg production, particularly showing efficacy against juvenile parasites, suggesting their potential as lead compounds for novel antischistosomal drugs.

ACTA TROPICA (2021)

Article Plant Sciences

Brazilian red propolis exhibits antiparasitic properties in vitro and reduces worm burden and egg production in an mouse model harboring either early or chronic Schistosoma mansoni infection

Marcos P. Silva et al.

Summary: The study demonstrates that Brazilian red propolis has significant anthelmintic properties against Schistosoma mansoni infection, reducing worm burden and egg production in both in vitro and in vivo studies.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

Article Chemistry, Medicinal

New evidence for tamoxifen as an antischistosomal agent: in vitro, in vivo and target fishing studies

Tais C. Silva et al.

Summary: The study demonstrated the anti-parasitic effect of tamoxifen against adult and immature schistosomes, with significant reduction in worm burden and egg production in mice. Target fishing investigation identified propionyl-CoA carboxylase as a potential target for tamoxifen in Schistosoma mansoni.

FUTURE MEDICINAL CHEMISTRY (2021)

Article Chemistry, Medicinal

Licarin A, a neolignan isolated from Nectandra oppositifolia Nees & Mart. (Lauraceae), exhibited moderate preclinical efficacy against Schistosoma mansoni infection

Ana C. Mengarda et al.

Summary: Schistosomiasis is a widespread human parasitic disease affecting over 200 million people, with praziquantel as the main chemotherapy. Studies show that licarin A (LIC-A) has potential antiparasitic activity against Schistosoma mansoni. LIC-A demonstrated partial cure in infected mice and moderate inhibition of parasite eggs, supporting its potential as a novel antischistosomal agent.

PHYTOTHERAPY RESEARCH (2021)

Editorial Material Parasitology

FDA-Approved Antiparasitic Drugs in the 21st Century: A Success for Helminthiasis?

Josue de Moraes et al.

TRENDS IN PARASITOLOGY (2020)

Article Pharmacology & Pharmacy

Schiff bases of 4-Phenyl-2-Aminothiazoles as hits to new antischistosomals: Synthesis, in vitro, in vivo and in silico studies

Carina R. Amorim et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

Article Microbiology

Therapeutic Effect of Diminazene Aceturate on Parasitic Blood Fluke Schistosoma mansoni Infection

Mariana G. de Britto et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2020)

Article Parasitology

H1-antihistamines as antischistosomal drugs: in vitro and in vivo studies

Rogerio P. Xavier et al.

PARASITES & VECTORS (2020)

Article Public, Environmental & Occupational Health

A Combination of Itraconazole and Amiodarone Is Highly Effective against Trypanosoma cruzi Infection of Human Stem Cell-Derived Cardiomyocytes

Gabriele Sass et al.

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2019)

Article Chemistry, Medicinal

Vanillin-Related N-Acylhydrazones: Synthesis, Antischistosomal Properties and Target Fishing Studies

Daniela G. G. Rando et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2019)

Article Microbiology

In Vitro and In Vivo Studies of Spironolactone as an Antischistosomal Drug Capable of Clinical Repurposing

Rafael A. Guerra et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2019)

Article Biochemical Research Methods

Life cycle maintenance and drug-sensitivity assays for early drug discovery in Schistosoma mansoni

Flavio C. Lombardo et al.

NATURE PROTOCOLS (2019)

Review Chemistry, Medicinal

Antischistosomal agents: state of art and perspectives

Eloi M. Lago et al.

FUTURE MEDICINAL CHEMISTRY (2018)

Article Multidisciplinary Sciences

Epiisopilosine alkaloid has activity against Schistosoma mansoni in mice without acute toxicity

Maria A. Guimaraes et al.

PLOS ONE (2018)

Article Medicine, General & Internal

Schistosomiasis

Donald P. McManus et al.

NATURE REVIEWS DISEASE PRIMERS (2018)

Article Infectious Diseases

Antiparasitic activity of nerolidol in a mouse model of schistosomiasis

Marcos P. Silva et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2017)

Review Infectious Diseases

Putting the treatment of paediatric schistosomiasis into context

Takafira Mduluza et al.

INFECTIOUS DISEASES OF POVERTY (2017)

Review Microbiology

Praziquantel for Schistosomiasis: Single-Drug Metabolism Revisited, Mode of Action, and Resistance

Nuno Vale et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2017)

Article Integrative & Complementary Medicine

Flavonoids and Sesquiterpene Lactones from Artemisia absinthium and Tanacetum parthenium against Schistosoma mansoni Worms

Luisa Maria Silveira de Almeida et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2016)

Review Parasitology

Discovery of Novel Antischistosomal Agents by Molecular Modeling Approaches

Ana C. Mafud et al.

TRENDS IN PARASITOLOGY (2016)

Review Parasitology

TRP channels in schistosomes

Swarna Bais et al.

INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE (2016)

Article Microbiology

Antischistosomal Activity of Oxindolimine-Metal Complexes

Josue de Moraes et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)

Review Chemistry, Medicinal

Natural products with antischistosomal activity

Josue de Moraes

FUTURE MEDICINAL CHEMISTRY (2015)

Article Biochemistry & Molecular Biology

A constitutively active G protein-coupled acetylcholine receptor regulates motility of larval Schistosoma mansoni

Kevin MacDonald et al.

MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2015)

Article Infectious Diseases

Phytol, a Diterpene Alcohol from Chlorophyll, as a Drug against Neglected Tropical Disease Schistosomiasis Mansoni

Josue de Moraes et al.

PLOS NEGLECTED TROPICAL DISEASES (2014)

Article Microbiology

Ion Channels and Drug Transporters as Targets for Anthelmintics

Robert M. Greenberg

CURRENT CLINICAL MICROBIOLOGY REPORTS (2014)

Review Pharmacology & Pharmacy

Examining the safety of amiodarone

Pasquale Santangeli et al.

EXPERT OPINION ON DRUG SAFETY (2012)

Article Pharmacology & Pharmacy

Examining the safety of amiodarone

Pasquale Santangeli et al.

EXPERT OPINION ON DRUG SAFETY (2012)

Article Pharmacology & Pharmacy

Novel Allosteric Effects of Amiodarone at the Muscarinic M5 Receptor

Edward Stahl et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2010)

Article Microbiology

Amiodarone Destabilizes Intracellular Ca2+ Homeostasis and Biosynthesis of Sterols in Leishmania mexicana

Xenon Serrano-Martin et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)

Article Infectious Diseases

Interference with Hemozoin Formation Represents an Important Mechanism of Schistosomicidal Action of Antimalarial Quinoline Methanols

Juliana B. R. Correa Soares et al.

PLOS NEGLECTED TROPICAL DISEASES (2009)

Article Biochemistry & Molecular Biology

Dose translation from animal to human studies revisited

Shannon Reagan-Shaw et al.

FASEB JOURNAL (2008)