Journal
PHARMACEUTICALS
Volume 14, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/ph14080715
Keywords
Hg-CATH; Pb-CATH4; herpes simplex virus I; keratinocytes; antiviral
Categories
Funding
- Agence Nationale de la Recherche [ANR17-CE35-0001-01]
- European Union
- New Aquitaine region through the Habisan program (CPER-FEDER)
- National Research Foundation of Korea, MSIT [2021R1A2C3010505]
- National Research Foundation of Korea [2021R1A2C3010505] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Hg-CATH and Pb-CATH4, derived from Heterocephalus glaber and Python bivittatus, were found to exhibit potent antiviral activity against herpes simplex virus, making them potential candidates for new therapies targeting HSV-1.
Hg-CATH and Pb-CATH4 are cathelicidins from Heterocephalus glaber and Python bivittatus that have been previously identified as potent antibacterial peptides. However, their antiviral properties were not previously investigated. In this study, their activity against the herpes simplex virus (HSV)-1 was evaluated during primary human keratinocyte infection. Both of them significantly reduced HSV-1 DNA replication and production of infectious viral particles in keratinocytes at noncytotoxic concentrations, with the stronger activity of Pb-CATH4. These peptides did not show direct virucidal activity and did not exhibit significant immunomodulatory properties, except for Pb-CATH4, which exerted a moderate proinflammatory action. All in all, our results suggest that Hg-CATH and Pb-CATH4 could be potent candidates for the development of new therapies against HSV-1.
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