Recent Advances in the Clinical Translation of Silicon Fluoride Acceptor (SiFA) 18F-Radiopharmaceuticals

The incorporation of silicon fluoride acceptor (SiFA) moieties into a variety of molecules, such as peptides, proteins and biologically relevant small molecules, has improved the generation of F-18-radiopharmaceuticals for medical imaging. The efficient isotopic exchange radiofluorination process, in combination with the enhanced [F-18]SiFA in vivo stability, make it a suitable strategy for fluorine-18 incorporation. This review will highlight the clinical applicability of [F-18]SiFA-labeled compounds and discuss the significant radiotracers currently in clinical use.

Automated summary

Incorporation of silicon fluoride acceptor (SiFA) moieties into various molecules has enhanced the generation of F-18 radiopharmaceuticals for medical imaging. The efficient isotopic exchange radiofluorination process, along with the enhanced in vivo stability of [F-18]SiFA, makes it a suitable strategy for fluorine-18 incorporation. This review emphasizes the clinical applicability of [F-18]SiFA-labeled compounds and discusses significant radiotracers currently in clinical use.