Journal
PHARMACEUTICALS
Volume 14, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/ph14080779
Keywords
pyrazinoindole; pyrazinoindolone; cyclization; catalysis; biological activity
Categories
Funding
- CNRS
- Universite Paris-Saclay
- CSC (Chinese Scholarship Council)
Ask authors/readers for more resources
This review summarizes the synthesis and biological activities of pyrazino[1,2-a]indoles and pyrazino[1,2-a]indol-1-ones reported since 1997, as well as the discovery of biological activity of pyrazinoindole derivatives. The review discusses synthetic routes to access the pyrazinoindole unit and the properties of pyrazinoindoles, including neuropsychiatric, auto-immune, anti-infectious, and anti-cancer properties. It also covers the main accesses to pyrazinoindol-1-one substrates and the properties of pyrazinoindolones, such as anti-cancer, anti-infectious, anti-allergenic, and neuropsychiatric properties.
This review concerns the synthesis and biological activities of pyrazino[1,2-a]indoles and pyrazino[1,2-a]indol-1-ones reported since 1997 and the discovery of biological activity of pyrazinoindole derivatives. In the first part, we first presented the synthetic routes that have been reported from a methodological point of view to access the pyrazinoindole unit according to cyclization reactions using or not using metal catalysts. Then, syntheses and neuropsychiatric, auto-immune, anti-infectious and anti-cancer properties of pyrazinoindoles were detailed. In the second part, we first reported the main accesses to pyrazinoindol-1-one substrates according to Michael reactions, metal-catalyzed and metal-free cyclization reactions. The syntheses and anti-cancer, anti-infectious, anti-allergenic and neuropsychiatric properties of pyrazinoindolones were next described and discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available