Journal
PHARMACEUTICALS
Volume 14, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/ph14060543
Keywords
endometriosis; PPAR gamma agonists; inflammation; angiogenesis; apoptosis; invasion; adhesion
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Endometriosis is a common gynecological disease characterized by inflammation, angiogenesis, invasion, adhesion, and apoptosis. The introduction of new agents like PPAR gamma ligands may be effective in improving the condition of patients, although data in humans remain limited.
Endometriosis is one of the major gynecological diseases of reproductive-age women. This disease is characterized by the presence of glands and stroma outside the uterine cavity. Several studies have shown the major role of inflammation, angiogenesis, adhesion and invasion, and apoptosis in endometriotic lesions. Nevertheless, the mechanisms underlying endometriotic mechanisms still remain unclear and therapies are not currently efficient. The introduction of new agents can be effective by improving the condition of patients. PPAR gamma ligands can directly modulate these pathways in endometriosis. However, data in humans remain low. Thus, the purpose of this review is to summarize the potential actions of PPAR gamma agonists in endometriosis by acting on inflammation, angiogenesis, invasion, adhesion, and apoptosis.
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