Journal
ISCIENCE
Volume 24, Issue 9, Pages -Publisher
CELL PRESS
DOI: 10.1016/j.isci.2021.103011
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Funding
- JNCASR Intramural funds
- DST-SERB [CRG/2019/006802]
- DST-INSPIRE
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Innexin2 plays a crucial role in determining the intrinsic period of activity-rest rhythms in Drosophila melanogaster, with knockdown of its expression leading to alterations in the oscillation of core-clock proteins and output molecules. Disrupting the channel-forming ability of Innexin2 causes period lengthening, suggesting it may act as hemichannels or gap junctions in the clock circuit.
A neuronal circuit of similar to 150 neurons modulates rhythmic activity-rest behavior of Drosophila melanogaster. While it is known that coherent similar to 24-hr rhythms in locomotion are brought aboutwhen 7 distinct neuronal clusters function as a network due to chemical communication amongst them, there are no reports of communication via electrical synapses made up of gap junctions. Here, we report that gap junction proteins, Innexins play crucial roles in determining the intrinsic period of activity-rest rhythms in flies. We show the presence of Innexin2 in the ventral lateral neurons, wherein RNAi-based knockdown of its expression slows down the speed of activity-rest rhythm along with alterations in the oscillation of a core- clock protein PERIOD and the output molecule pigment dispersing factor. Specifically disrupting the channel-forming ability of Innexin2 causes period lengthening, suggesting that Innexin2 may function as hemichannels or gap junctions in the clock circuit.
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