SISTEMA: A large and standardized collection of transcriptome data sets for human pluripotent stem cell research

Human pluripotent stem cells have ushered in an exciting new era for disease modeling, drug discovery, and cell therapy development. Continued progress toward realizing the potential of human pluripotent stem cells will be facilitated by robust data sets and complementary resources that are easily accessed and interrogated by the stem cell community. In this context, we present SISTEMA, a quality-controlled curated gene expression database, built on a valuable catalog of human pluripotent stem cell lines, and their derivatives for which transcriptomic analyses have been generated using a single experimental pipeline. SISTEMA functions as a one-step resource that will assist the stem cell community to easily evaluate the expression level for genes of interest, while comparing them across different hPSC lines, cell types, pathological conditions, or after pharmacological treatments.

Automated summary

Human pluripotent stem cells have brought forth a new era in disease modeling, drug discovery, and cell therapy development. SISTEMA, a curated gene expression database, serves as a one-stop resource for the stem cell community to easily evaluate gene expression levels and compare them across different conditions.