Journal
ISCIENCE
Volume 24, Issue 8, Pages -Publisher
CELL PRESS
DOI: 10.1016/j.isci.2021.102842
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Funding
- National Blood Foundation Scholar Award
- National Institutes of Health (NIH) [L6 MD0010106, K22 (AI130182)]
- Upstate Medical University Cancer grant [1146249-1-75632]
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This review explores the role of ITK signaling in multiple diseases, including T cell-derived malignancies, allergic diseases, infectious diseases, autoimmune disorders, and the potential use of ITK inhibition in transplantation recipients.
The focus of this review is to examine the role of ITK signaling in multiple diseases and investigate the clinical potential of ITK inhibition. The diseases and potential interventions reviewed include T cell-derived malignancies as well as other neoplastic diseases, allergic diseases such as asthma and atopic dermatitis, certain infectious diseases, several autoimmune disorders such as rheumatoid arthritis and psoriasis, and finally the use of ITK inhibition in both solid organ and bone marrow transplantation recipients.
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