Journal
JOURNAL OF FUNGI
Volume 7, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/jof7090729
Keywords
yeast; cytokinesis; actomyosin ring; septum; cell integrity
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Funding
- MEIC, Spain [BFU2017-84508-P, PID2020-115111GB-I00]
- Regional Government of Castile and Leon [SA116G19]
- Junta de Castilla y Leon through the program Escalera de Excelencia - PO FEDER of Castilla y Leon 14-20 [CLU-2017-03]
- FPU fellowship from the Spanish Ministry of Education
- University of Salamanca
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Cytokinesis divides a mother cell into two daughter cells using a contractile actomyosin ring (CAR), contributing to genome integrity. While differences exist in the final steps of cytokinesis in animal cells and yeast, the signalling pathways play a critical role in cell wall remodeling during cytokinesis in yeast.
Cytokinesis divides a mother cell into two daughter cells at the end of each cell cycle and proceeds via the assembly and constriction of a contractile actomyosin ring (CAR). Ring constriction promotes division furrow ingression, after sister chromatids are segregated to opposing sides of the cleavage plane. Cytokinesis contributes to genome integrity because the cells that fail to complete cytokinesis often reduplicate their chromosomes. While in animal cells, the last steps of cytokinesis involve extracellular matrix remodelling and mid-body abscission, in yeast, CAR constriction is coupled to the synthesis of a polysaccharide septum. To preserve cell integrity during cytokinesis, fungal cells remodel their cell wall through signalling pathways that connect receptors to downstream effectors, initiating a cascade of biological signals. One of the best-studied signalling pathways is the cell wall integrity pathway (CWI) of the budding yeast Saccharomyces cerevisiae and its counterpart in the fission yeast Schizosaccharomyces pombe, the cell integrity pathway (CIP). Both are signal transduction pathways relying upon a cascade of MAP kinases. However, despite strong similarities in the assembly of the septa in both yeasts, there are significant mechanistic differences, including the relationship of this process with the cell integrity signalling pathways.
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