Oviductal Telocytes in Patients with Uterine Myoma

Tubal factor infertility occurs in 30-35% of infertile pairs and may be caused by impaired muscular contractility and ciliary beating as well as immunological imbalance and chronic inflammation. Newly discovered telocytes (TCs) have a wide palette of features, which play a role in oviduct physiology. We have observed tissue samples from human fallopian tubes in patients with and without uterine myoma by immunolabelling. According to the immunohistochemical co-expression of markers, it has been determined that TCs are engaged in a wide range of physiological processes, including local innervation, sensitivity to hypoxia, regulation of calcium, and sex steroid hormones balances. Due to the proximity of NOS- and ChAT-positive nerve fibers and the expression of ion channels markers, tubal TCs might be considered conductor cells. Additionally, their integration in contractions and cilia physiology in the context of fertility has been revealed. We have observed the difference in telocytes expression in the human oviduct between groups of patients and attempted to describe this population of cells specifically in the case of infertility development, a clinically relevant avenue for further studies.

Automated summary

Tubal factor infertility can be caused by various factors, including impaired muscular contractility and ciliary beating, immunological imbalance, and chronic inflammation. Telocytes in the fallopian tubes play a crucial role in regulating physiological processes such as local innervation, sensitivity to hypoxia, and hormone balances. Their involvement in nerve conduction and integration in contractions and cilia physiology highlight their significance in fertility research.