Natural Products, Alone or in Combination with FDA-Approved Drugs, to Treat COVID-19 and Lung Cancer

Article Chemistry, Medicinal

Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse Models

Yingjun Li et al.

Summary: The article reports that the parent nucleoside of remdesivir, GS-441524, shows potent inhibition of SARS-CoV-2 replication and has high efficacy in reducing viral titers in infected organs without notable toxicity in animal studies.

JOURNAL OF MEDICINAL CHEMISTRY (2022)

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Article Cell Biology

RING finger protein 38 induces the drug resistance of cisplatin in non-small-cell lung cancer

Chao Wu et al.

Summary: The study reveals that high expression of RNF38 in NSCLC cells can induce cisplatin resistance by promoting cell apoptosis. RNF38 could potentially be a novel target for overcoming cisplatin resistance in NSCLC cases.

CELL BIOLOGY INTERNATIONAL (2021)

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Article Cell Biology

Inhibitory effect of sinomenine on lung cancer cells via negative regulation of α7 nicotinic acetylcholine receptor

Shasha Bai et al.

Summary: The study showed that sinomenine inhibits the proliferation and migration abilities of lung cancer cells, increases apoptosis, and suppresses tumor growth by targeting the alpha 7 nAChR. The inhibitory effects are influenced by specific antagonists, suggesting that sinomenine may play a significant role in lung cancer treatment.

JOURNAL OF LEUKOCYTE BIOLOGY (2021)

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Article Engineering, Environmental

Tumor-specific carrier-free nanodrugs with GSH depletion and enhanced ROS generation for endogenous synergistic anti-tumor by a chemotherapy-photodynamic therapy

Jin-Shuai Lan et al.

Summary: Combining chemotherapy and photodynamic therapy with a novel carrier-free nanodrug has shown promising results in enhancing treatment efficacy, indicating that depleting GSH through chemotherapy can improve the effectiveness of PDT.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Pharmacology & Pharmacy

Cryptotanshinone strengthens the effect of gefitinib against non-small cell lung cancer through inhibiting transketolase

Lin Cao et al.

Summary: Lung cancer is the leading cause of cancer-related deaths, with gefitinib being a first-line treatment facing challenges in resistance. Research found up-regulated TKT expression in lung cancer cells, with CTS enhancing the effect of gefitinib by inhibiting TKT, potentially serving as a new adjuvant therapy for advanced lung cancer.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Article Oncology

Glochidiol, a natural triterpenoid, exerts its anti-cancer effects by targeting the colchicine binding site of tubulin

Hongjie Chen et al.

Summary: Glochidiol has potent antiproliferative activity against lung cancer cell lines both in vitro and in vivo, potentially through inhibiting tubulin polymerization and interacting with the colchicine binding site, making it a novel colchicine binding site inhibitor with potential to treat lung cancer.

INVESTIGATIONAL NEW DRUGS (2021)

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Review Gastroenterology & Hepatology

COVID-19: Discovery, diagnostics and drug development

Tarik Asselah et al.

Summary: COVID-19 started in Wuhan in 2019 and has become a global pandemic. The virus responsible, SARS-CoV-2, shares a high sequence identity with bat- and pangolin-derived coronaviruses. Risk factors for SARS-CoV-2 infection include age, obesity, diabetes, and hypertension.

JOURNAL OF HEPATOLOGY (2021)

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Review Pharmacology & Pharmacy

Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

Yu-Qiong He et al.

Summary: ALI and ARDS are common life-threatening lung diseases with high mortality rates, but there is still a lack of effective pharmacological therapies. Developing new drugs for therapy of ALI/ARDS is in great demand, as natural compounds have shown potential therapeutic effects and may also be helpful for treatment of COVID-19.

PHARMACOLOGICAL RESEARCH (2021)

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Editorial Material Pharmacology & Pharmacy

Naringenin is a powerful inhibitor of SARS-CoV-2 infection in vitro

Nicola Clementi et al.

PHARMACOLOGICAL RESEARCH (2021)

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Article Plant Sciences

Licochalcone A inhibits interferon-gamma-induced programmed death-ligand 1 in lung cancer cells

Luo-Wei Yuan et al.

Summary: The study found that Licochalcone A can interfere with the expression of IFN-gamma-induced PD-L1 in lung cancer cells by inhibiting protein translation, especially through ROS generation, suggesting its potential for cancer immunotherapy.

PHYTOMEDICINE (2021)

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Article Biochemistry & Molecular Biology

Kaempferol inhibits Nrf2 signalling pathway via downregulation of Nrf2 mRNA and induces apoptosis in NSCLC cells

Chandrani Fouzder et al.

Summary: Kaempferol has been identified as a potent inhibitor of Nrf2, reducing the expression of Nrf2 and its target genes in NSCLC cells. Additionally, it induces ROS accumulation and sensitizes the cells to apoptosis.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2021)

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Article Pharmacology & Pharmacy

The comprehensive study on the therapeutic effects of baicalein for the treatment of COVID-19 in vivo and in vitro

Junke Song et al.

Summary: Baicalein, the main active compound of Scutellaria baicalensis Georgi, has shown potential therapeutic effects against COVID-19 by inhibiting SARS-CoV-2-induced cell damage and displaying anti-viral and anti-inflammatory properties in various in vitro and in vivo models.

BIOCHEMICAL PHARMACOLOGY (2021)

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Article Medicine, Research & Experimental

Baicalein suppresses growth of non-small cell lung carcinoma by targeting MAP4K3

Jian Li et al.

Summary: This study identifies MAP4K3 protein kinase as an important regulator in the development and treatment of non-small cell lung carcinoma (NSCLC). Baicalein, a natural product, is shown to induce autophagy in NSCLC cells by degrading MAP4K3, providing a potential therapeutic target for NSCLC treatment.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Biochemical Research Methods

Transcriptome analysis of cepharanthine against a SARS-CoV-2-related coronavirus

Shasha Li et al.

Summary: This study identified cepharanthine (CEP) as an effective antiviral agent against a SARS-CoV-2-related virus, reversing dysregulated genes and pathways associated with cellular stress response and heat shock response. Single-cell transcriptomes analysis also showed enrichment of genes related to cellular stress responses and autophagy pathways in peripheral blood mononuclear cells from COVID-19 patients.

BRIEFINGS IN BIOINFORMATICS (2021)

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Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Pharmacology & Pharmacy

Unravelling high-affinity binding compounds towards transmembrane protease serine 2 enzyme in treating SARS-CoV-2 infection using molecular modelling and docking studies

M. Pooja et al.

Summary: The COVID-19 pandemic has prompted the search for effective drug candidates due to the lack of vaccines and drugs. This study focused on the TMPRSS2 enzyme as a potential pharmacological target and identified eight high affinity drug candidates through modeling and molecular docking studies.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

Assessment of antiviral potencies of cannabinoids against SARS-CoV-2 using computational and in vitro approaches

Vinit Raj et al.

Summary: This study evaluated the antiviral activity of cannabinoids (CBDs) against SARS-CoV-2 and found that two CBDs molecules, cannabidiol and Delta(9)-tetrahydrocannabinol, may be more potent antiviral molecules against the virus compared to some reference drugs. They could be potential options for treating COVID-19 patients.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Cell Biology

Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor

Sarah O'Keefe et al.

Summary: The study found that the small molecule inhibitor Ipom-F can effectively block the synthesis of SARS-CoV-2 infection proteins to reduce pathogenicity, suggesting a new strategy for antiviral drugs.

JOURNAL OF CELL SCIENCE (2021)

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Article Cell Biology

Licochalcone A inhibits EGFR signalling and translationally suppresses survivin expression in human cancer cells

Feng Gao et al.

Summary: In this study, it was found that licochalcone A exhibited anti-tumor efficacy in NSCLC cells by directly targeting EGFR signaling, inducing apoptosis, and decreasing survivin protein levels. By inhibiting EGFR kinase activity and downstream pathways, licochalcone A may serve as a potential therapeutic agent for NSCLC.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Cell Biology

Celastrol acts synergistically with afatinib to suppress non-small cell lung cancer cell proliferation by inducing paraptosis

Chun-Hau Dai et al.

Summary: This study demonstrated that celastrol synergistically induced paraptosis with afatinib in NSCLC cells, independent of apoptosis and autophagy induction. The combination of celastrol and afatinib also effectively suppressed the growth of H23 cell xenograft tumors in vivo. These findings suggest that the combination of afatinib and celastrol may be a promising therapeutic strategy to overcome intrinsic afatinib resistance in NSCLC cells.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro

Hongbo Liu et al.

Summary: The study showed that Scutellaria baicalensis and its major component baicalein can inhibit the activity of SARS-CoV-2, demonstrating potential as broad-spectrum anti-coronavirus drugs in both in vitro and cell culture settings.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2021)

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Review Plant Sciences

Chinese herbal medicine: Fighting SARS-CoV-2 infection on all fronts

Zhonglei Wang et al.

Summary: Traditional Chinese herbal medicines have shown promising potential for treating COVID-19, including active ingredients, monomer preparations, crude extracts, and formulas, all of which have potential activity against SARS-CoV-2 and have shown significant effects both in vitro and in clinical practice. As a key component of the COVID-19 treatment regimen, Chinese herbal medicines have played an irreplaceable role in the treatment of SARS-CoV-2 infection.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Review Plant Sciences

Natural Products with Potential to Treat RNA Virus Pathogens Including SARS-CoV-2

Mitchell P. Christy et al.

Summary: This review provides fundamental information on three families of RNA viruses: Coronaviridae, Flaviviridae, and Filoviridae. It highlights the lack of effective medications currently available to treat these virus families and explores potential natural product-based therapeutic strategies.

JOURNAL OF NATURAL PRODUCTS (2021)

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Letter Chemistry, Medicinal

Resveratrol inhibits the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in cultured Vero cells

Minghui Yang et al.

PHYTOTHERAPY RESEARCH (2021)

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Article Plant Sciences

Erianthridin Induces Non-small Cell Lung Cancer Cell Apoptosis through the Suppression of Extracellular Signal-regulated Kinase Activity

Sirima Boonjing et al.

Summary: Erianthridin, a compound isolated from Dendrobium formosum, has shown promising cytotoxic effects in non-small cell lung cancer cells by inducing apoptosis. Mechanistic studies indicate that erianthridin can modulate apoptosis-related protein markers and mediate apoptosis through the regulation of Bcl-2 family proteins. In vitro assays demonstrate the potential of erianthridin to suppress lung cancer cell proliferation.

PLANTA MEDICA (2021)

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Article Multidisciplinary Sciences

Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection

Jia-Tsrong Jan et al.

Summary: The COVID-19 pandemic has resulted in over 50 million confirmed cases and more than 1 million deaths globally as of November 2020. Currently, there are no effective antivirals approved by the FDA, posing a major challenge in vaccine development. Alternative treatments are urgently needed.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Biotechnology & Applied Microbiology

ERK Activation-Mediated Autophagy Induction Resists Licochalcone A-Induced Anticancer Activities in Lung Cancer Cells in vitro

Wei Luo et al.

Summary: The study revealed that LA inhibits NSCLC cell proliferation in a dose-dependent manner and induces apoptotic cell death. LA significantly suppresses the expression of several apoptosis-related proteins without affecting mRNA levels. Mechanistic studies suggest that LA induces cytoprotective autophagy, and further experiments show that LA activates ERK and p38 pathways while suppressing JNK pathway, leading to enhanced cytotoxicity in lung cancer cells.

ONCOTARGETS AND THERAPY (2021)

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Article Chemistry, Medicinal

Gracillin Isolated from Reineckia carnea Induces Apoptosis of A549 Cells via the Mitochondrial Pathway

Jianqiong Yang et al.

Summary: Gracillin, isolated from Reineckia carnea for the first time, showed significant antiproliferative effect on A549 cells and induced apoptosis through the mitochondrial pathway by regulating intracellular calcium concentration, mitochondrial membrane potential, and expression levels of apoptosis-related proteins.

DRUG DESIGN DEVELOPMENT AND THERAPY (2021)

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Article Pharmacology & Pharmacy

An Integrated Strategy for Effective-Component Discovery of Astragali Radix in the Treatment of Lung Cancer

Bing Yang et al.

Summary: This study established an integrated strategy for effective-component discovery of traditional Chinese medicine Astragali Radix in the treatment of lung cancer. Through network pharmacology, in vivo evaluation, and in vitro metabolism analysis, potential effective components and targets related to autophagy and the p53/AMPK/mTOR signaling pathway were identified. This integrated strategy provides a valuable mode for finding the pharmacodynamic material basis of complex traditional Chinese medicine systems and lays the foundation for further mechanistic studies on Astragali Radix in lung cancer treatment.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Pharmacology & Pharmacy

Pure redox-sensitive paclitaxele-maleimide prodrug nanoparticles: Endogenous albumin-induced size switching and improved antitumor efficiency

Xinyu Lou et al.

Summary: This study presents an albumin-bound tumor redox-responsive paclitaxel prodrugs nano-delivery strategy, which enhances drug accumulation in tumor regions and improves the selectivity of cytotoxicity between cancer cells through rapid disintegration of prodrug nanoparticles in vivo.

ACTA PHARMACEUTICA SINICA B (2021)

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Article Pharmacology & Pharmacy

Emetine suppresses SARS-CoV-2 replication by inhibiting interaction of viral mRNA with eIF4E

Ram Kumar et al.

Summary: Emetine has been shown to have antiviral effects against SARS-CoV-2 and infectious bronchitis virus by interfering with viral RNA synthesis and disrupting its binding with cellular proteins. Further research on emetine as a potential treatment for COVID-19 is warranted.

ANTIVIRAL RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Vincamine, a safe natural alkaloid, represents a novel anticancer agent

Sarah Al-Rashed et al.

Summary: The study demonstrated that Vincamine exhibited anticancer properties in A549 cells by stimulating caspase-3-dependent apoptosis, reducing mitochondrial membrane potential, and inducing cytochrome C release. Vincamine was also shown to quench free radicals and deplete iron ions in cancer cells, with minimal toxicity in BEAS-2B and 3T3-L1 cells. It is proposed as a safe anticancer agent in lung cancer cells, with potential roles in other cancers yet to be explored.

BIOORGANIC CHEMISTRY (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Agricultural Engineering

Exogenous hormone on episperm development and ginkgolic acid accumulation in Ginkgo biloba L

Junru Yang et al.

Summary: Ginkgolic acid is a phenolic acid specifically distributed in Ginkgo biloba, with potential applications in improving ginkgolic acid accumulation in G. biloba seeds. The study found a close relationship between the variation of endogenous hormone levels and ginkgolic acid content during the development of G. biloba episperms. Exogenous hormone treatment significantly increased episperm yield and ginkgolic acid content in developing G. biloba fruits, providing a cost-effective way to enhance ginkgolic acid accumulation.

INDUSTRIAL CROPS AND PRODUCTS (2021)

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Article Plant Sciences

Antiviral Bafilomycins from a Feces-Inhabiting Streptomyces sp.

Xi Xie et al.

Summary: A new bafilomycin derivative and known bafilomycins isolated from Streptomyces sp. HTL16 showed potent antiviral activities against influenza A and SARS-CoV-2 viruses by inhibiting endosomal ATP-driven proton pumps, with IC50 values in the nanomolar range.

JOURNAL OF NATURAL PRODUCTS (2021)

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Article Plant Sciences

Axial Chiral Binaphthoquinone and Perylenequinones from the Stromata of Hypocrella bambusae Are SARS-CoV-2 Entry Inhibitors

Yu-Ting Li et al.

Summary: A new axial chiral binaphtoquinone and a new perylenequinone were isolated from the stromata of Hypocrella bambusae and showed inhibitory activity against SARS-CoV-2 infection. These compounds were found to potentially bind with the receptor-binding domain of SARS-CoV-2 S protein, indicating their potential as entry inhibitors for the virus.

JOURNAL OF NATURAL PRODUCTS (2021)

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Article Chemistry, Physical

Kobophenol A Inhibits Binding of Host ACE2 Receptor with Spike RBD Domain of SARS-CoV-2, a Lead Compound for Blocking COVID-19

Suresh Gangadevi et al.

Summary: The study revealed that Kobophenol A, identified through virtual screening, could potentially serve as an inhibitor for COVID-19 by blocking the interaction between the virus and cells, inhibiting viral infection. Molecular dynamics simulations indicated strong affinity of Kobophenol A to the ACE2 receptor, making it a promising compound for antiviral therapy.

JOURNAL OF PHYSICAL CHEMISTRY LETTERS (2021)

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Article Materials Science, Biomaterials

Targeted delivery of quercetin by nanoparticles based on chitosan sensitizing paclitaxel-resistant lung cancer cells to paclitaxel

Yonghong Wang et al.

Summary: The study showed that quercetin (QUE) could reverse the resistance of non-small cell lung cancer (NSCLC) to paclitaxel (PTX). By preparing targeted biodegradable cetuximab chitosan nanoparticles (Cet-CTS NPs) to deliver PTX and QUE, the growth of PTX-resistant tumor cells was successfully inhibited.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Review Biochemistry & Molecular Biology

The need for precision nutrition, genetic variation and resolution in Covid-19 patients

Artemis P. Simopoulos et al.

Summary: The health of individuals and populations is influenced by a complex interplay between genetics and environmental factors, with diet/nutrition playing a crucial role. Imbalances in essential fatty acids such as high N-6 PUFA and low N-3 PUFA may lead to inflammatory conditions and are linked to various diseases.

MOLECULAR ASPECTS OF MEDICINE (2021)

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Review Biotechnology & Applied Microbiology

Natural products in drug discovery: advances and opportunities

Atanas G. Atanasov et al.

Summary: Natural products and their analogues have historically played a significant role in pharmacotherapy, however, they also present challenges. Recent technological and scientific developments are addressing these challenges and revitalizing interest in natural products as drug leads, particularly for combating antimicrobial resistance.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Article Multidisciplinary Sciences

SARS-CoV-2 M-pro inhibitors with antiviral activity in a transgenic mouse model

Jingxin Qiao et al.

Summary: The study designed and synthesized 32 new M-pro inhibitors containing bicycloproline, which showed inhibitory effects on SARS-CoV-2. Compounds MI-09 and MI-30 exhibited excellent antiviral activity in cell-based assays and significantly reduced lung viral loads and lung lesions in a transgenic mouse model of SARS-CoV-2 infection. Both also displayed good pharmacokinetic properties and safety in rats.

SCIENCE (2021)

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Article Toxicology

Crosstalk between alveolar macrophages and alveolar epithelial cells/fibroblasts contributes to the pulmonary toxicity of gefitinib

Jiangxia Du et al.

Summary: Gefitinib-induced pulmonary toxicity is characterized by the contribution of alveolar macrophages to promoting epithelial to mesenchymal transition in alveolar epithelial cells and inducing activation and antiapoptotic effect in fibroblasts, with MCP-1 playing a key role in the pathologic changes of these cell types. Inhibition of MCP-1 or STAT3 activation may serve as novel therapeutic strategies for preventing gefitinib-induced pulmonary toxicity.

TOXICOLOGY LETTERS (2021)

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Article Oncology

Quercetin induces pro-apoptotic autophagy via SIRT1/AMPK signaling pathway in human lung cancer cell lines A549 and H1299 in vitro

Hengjuan Guo et al.

Summary: Quercetin-induced autophagy contributes to apoptosis in A549 and H1299 lung cancer cells, involving the SIRT1/AMPK signaling pathway.

THORACIC CANCER (2021)

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Article Biochemistry & Molecular Biology

Ginkgolic acid and anacardic acid are specific covalent inhibitors of SARS-CoV-2 cysteine proteases

Zinuo Chen et al.

Summary: The study identified two natural products, ginkgolic acid and anacardic acid, as inhibitors of SARS-CoV-2, with dual inhibition effects on both the papain-like protease (PLpro) and the 3-chymotrypsin-like protease (3CL(pro)). These compounds were characterized as irreversible inhibitors against both 3CL(pro) and PLpro, and were found to inhibit SARS-CoV-2 replication in vitro at nontoxic concentrations, showing promise as potential antivirals against SARS-CoV-2.

CELL AND BIOSCIENCE (2021)

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Review Oncology

Perspectives and controversies regarding the use of natural products for the treatment of lung cancer

Tingting Wen et al.

Summary: Lung cancer is the leading cause of cancer-related mortality in both men and women. Over the years, natural compounds extracted from natural products have been found to be potentially useful in treating lung cancer, but there has not been a corresponding increase in the number of drugs used in clinical settings.

CANCER MEDICINE (2021)

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Article Pharmacology & Pharmacy

Corilagin inhibits SARS-CoV-2 replication by targeting viral RNA-dependent RNA polymerase

Quanjie Li et al.

Summary: Corilagin has been identified as a non-nucleoside inhibitor of SARS-CoV-2 RdRp, effectively inhibiting polymerase activity and showing potential therapeutic effects against SARS-CoV-2 infection. Combining corilagin with remdesivir also enhances the efficacy against SARS-CoV-2 RdRp.

ACTA PHARMACEUTICA SINICA B (2021)

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Article Oncology

Toxicarioside O Inhibits Cell Proliferation and Epithelial-Mesenchymal Transition by Downregulation of Trop2 in Lung Cancer Cells

Wu-Ping Zheng et al.

Summary: The study found that TCO effectively inhibits proliferation and induces apoptosis in lung cancer cells, while also suppressing cell migration and the EMT program. Mechanistically, TCO inhibits the PI3K/Akt pathway and EMT program by reducing Trop2 expression, indicating its potential as an anticancer agent.

FRONTIERS IN ONCOLOGY (2021)

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Article Cell Biology

被撤回的出版物: Parthenolide Augments the Chemosensitivity of Non-small-Cell Lung Cancer to Cisplatin via the PI3K/AKT Signaling Pathway (Retracted article. See vol. 9, 2021)

Li-Mei Wu et al.

Summary: Although cisplatin-based chemotherapy can improve the prognosis of patients with non-small-cell lung cancer (NSCLC), chemotherapy resistance remains a major obstacle to curing the disease. Combining parthenolide (PTL) and cisplatin (DDP) has been shown to synergistically inhibit NSCLC growth by affecting the PI3K-AKT signaling pathway. This combination therapy may offer a new option for treating NSCLC.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Baicalin Induces Apoptosis and Suppresses the Cell Cycle Progression of Lung Cancer Cells Through Downregulating Akt/mTOR Signaling Pathway

Xinbing Sui et al.

Summary: Baicalin, a natural active ingredient from Scutellaria baicalensis Georgi, has shown potential antitumor effects against various cancer types. The study revealed that baicalin exerts its antitumor activity mainly by inducing Akt-dependent cell cycle arrest and promoting apoptosis in lung cancer cells, suggesting it may be a promising candidate for developing new drugs for lung cancer treatment.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Article Chemistry, Medicinal

Repurposing of Some Natural Product Isolates as SARS-COV-2 Main Protease Inhibitors via In Vitro Cell Free and Cell-Based Antiviral Assessments and Molecular Modeling Approaches

Hossam M. Abdallah et al.

Summary: Through virtual screening, researchers identified five natural products that showed activity against the SARS-CoV-2 main protease, with naringenin displaying moderate antiviral activity. These findings pave the way for the future development of potential antiviral drugs to combat COVID-19.

PHARMACEUTICALS (2021)

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Review Medicine, Research & Experimental

Active ingredients from Chinese medicine plants as therapeutic strategies for asthma: Overview and challenges

Wenqian Wang et al.

Summary: Active ingredients from Chinese medicine have multilevel effects on asthma by regulating the immunologic equilibrium mechanism or signaling pathways, giving them great clinical value. However, the safety and functional mechanism of these ingredients still must be further determined.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Chemistry, Medicinal

A grafted peptidomimetic for EGFR heterodimerization inhibition: Implications in NSCLC models

Sitanshu S. Singh et al.

Summary: This study developed grafted peptides to inhibit protein-protein interactions of EGFR and HER2 in NSCLC, with SFTI-G5 showing promising antiproliferative activity. In vivo experiments demonstrated that SFTI-G5 could inhibit tumor growth and reduce EGFR dimerization, indicating its potential as a novel dual inhibitor in NSCLC.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

Epigallocatechin-3-gallate, an active ingredient of Traditional Chinese Medicines, inhibits the 3CLpro activity of SARS-CoV-2

Ashuai Du et al.

Summary: SARS-CoV-2 main protease 3CLpro is an attractive antiviral target, and epigallocatechin-3-gallate (EGCG) from Chinese herbal medicine (CHM) has been identified as a potent inhibitor of 3CLpro. Multiple strategies were used to screen inhibitors from traditional Chinese medicines, and the study provides critical insights into the potential therapeutic effect of EGCG against COVID-19.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Plant Sciences

Anti-esophageal Cancer Effect of Corilagin Extracted from Phmllanthi Fructus via the Mitochondrial and Endoplasmic Reticulum Stress Pathways

Chaoqun Wu et al.

Summary: Corilagin exhibits significant anti-esophageal cancer activity in both in vitro and in vivo experiments, possibly by activating mitochondrial and endoplasmic reticulum stress signaling pathways.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Plant Sciences

Anti-SARS-CoV-2 Activity of Andrographis paniculata Extract and Its Major Component Andrographolide in Human Lung Epithelial Cells and Cytotoxicity Evaluation in Major Organ Cell Representatives

Khanit Sa-ngiamsuntorn et al.

Summary: This study investigated the anti-SARS-CoV-2 activity of Andrographis paniculata extract and andrographolide in human lung epithelial cells, showing that they significantly inhibited the production of infectious virions with low cytotoxicity. These findings suggest that A. paniculata and andrographolide have potential as monotherapy or in combination with other drugs against SARS-CoV-2 infection.

JOURNAL OF NATURAL PRODUCTS (2021)

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Review Biochemistry & Molecular Biology

Post-acute COVID-19 syndrome

Ani Nalbandian et al.

Summary: SARS-CoV-2 is responsible for the COVID-19 pandemic, causing global healthcare crises. Recovery from COVID-19 may lead to persistent symptoms and long-term complications, prompting the need for multidisciplinary care and follow-up for survivors.

NATURE MEDICINE (2021)

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Review Pharmacology & Pharmacy

Deguelin targets multiple oncogenic signaling pathways to combat human malignancies

Hardeep Singh Tuli et al.

Summary: Deguelin, a natural rotenoid from plants, has shown promising antineoplastic effects in different cancer subtypes by inhibiting tumor growth and metastasis through various signaling pathways. Initial scientific findings suggest deguelin as a potential anticancer agent for monotherapy or in combination with chemotherapy.

PHARMACOLOGICAL RESEARCH (2021)

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Article Pharmacology & Pharmacy

Polyphyllin I reverses the resistance of osimertinib in non-small cell lung cancer cell through regulation of PI3K/Akt signaling

Lei Lai et al.

Summary: The study demonstrates that Polyphyllin I can reverse the resistance of osimertinib by promoting apoptosis, modulating the PI3K/Akt signaling, and regulating the expression of apoptosis-related proteins. Both in vitro and in vivo experiments confirmed this conclusion.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2021)

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Article Multidisciplinary Sciences

Erianthridin suppresses non-small-cell lung cancer cell metastasis through inhibition of Akt/mTOR/p70S6K signaling pathway

Sutthaorn Pothongsrisit et al.

Summary: Erianthridin (ETD) inhibits cell migration and invasion by disrupting actin stress fibers and lamellipodia formation, downregulating MMP-2 and MMP-9 expression. It also attenuates Akt/mTOR/p70(S6K) signaling pathway, leading to suppression of lung cancer metastasis. These findings suggest ETD as a promising antimetastatic agent against non-small-cell lung cancer.

SCIENTIFIC REPORTS (2021)

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Article Pharmacology & Pharmacy

The Cardenolide Glycoside Acovenoside A Interferes with Epidermal Growth Factor Receptor Trafficking in Non-Small Cell Lung Cancer Cells

Susanne Hafner et al.

Summary: Cardenolide glycosides inhibit the ion pumping function of Na+/K+-ATPase, leading to cancer cell death. This may be mediated by Src kinase activation and modulation of EGFR stability, affecting EGFR trafficking to endosomal compartments.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Microbiology

Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA Polymerase

Keivan Zandi et al.

Summary: COVID-19, caused by SARS-CoV-2, has become a global pandemic with no effective antiviral treatment available. Studies have shown that baicalein and baicalin exhibit significant antiviral activity against SARS-CoV-2 and could potentially be developed as therapeutic agents for COVID-19.

MICROORGANISMS (2021)

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Article Pharmacology & Pharmacy

Discovery of chebulagic acid and punicalagin as novel allosteric inhibitors of SARS-CoV-2 3CLpro

Ruikun Du et al.

Summary: The study found that chebulagic acid and punicalagin can inhibit the replication of SARS-CoV-2 virus in cells, and reduce virus-induced plaque formation at noncytotoxic concentrations, by regulating the enzymatic activity of viral protease as allosteric regulators.

ANTIVIRAL RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Novel inhibitors of the main protease enzyme of SARS-CoV-2 identified via molecular dynamics simulation-guided in vitro assay

Jennifer Loschwitz et al.

Summary: This study identifies eight compounds, including corilagin and lurasidone, as promising inhibitors of the SARS-CoV-2 main protease through molecular dynamics simulations and fluorescence assays. Additionally, testosterone is found to possess moderate inhibitory potency against 3CLpro, possibly explaining the increased severity of COVID-19 in older men.

BIOORGANIC CHEMISTRY (2021)

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Article Agriculture, Multidisciplinary

Epigallocatechin Gallate Inhibits the Uridylate-Specific Endoribonuclease Nsp15 and Efficiently Neutralizes the SARS-CoV-2 Strain

Seokho Hong et al.

Summary: SARS-CoV-2 and its variants present challenges to vaccine development and treatment. Natural compounds like EGCG, baicalin, and quercetin have been identified as potential inhibitors against the virus, with EGCG showing potent antiviral activity.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

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Article Plant Sciences

Erianin regulates programmed cell death ligand 1 expression and enhances cytotoxic T lymphocyte activity

Ao Yang et al.

Summary: Dendrobium chrysotoxum Lindl is a traditional Chinese medicine with various clinical applications. Erianin, a key component, has been shown to inhibit PD-L1 expression and interfere with HIF-1? synthesis through specific pathways. Additionally, erianin has demonstrated anti-proliferative effects and restored cytotoxic T lymphocytes ability, suggesting potential for improving immunotherapy against cervical cancer and other malignancies.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Biochemical Research Methods

Rutin and flavone analogs as prospective SARS-CoV-2 main protease inhibitors: In silico drug discovery study

Mahmoud A. A. Ibrahim et al.

Summary: COVID-19 is a new pandemic caused by SARS-CoV-2, and current therapies are limited. Flavonoids, especially rutin, have shown potential as inhibitors of the SARS-CoV-2 M-pro. Screening of 371 flavone analogs revealed two with better binding affinities than rutin, suggesting they may be promising drug candidates for further research.

JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2021)

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Review Pharmacology & Pharmacy

Traditional Chinese Medicine (TCM) in the treatment of COVID-19 and other viral infections: Efficacies and mechanisms

Kai Huang et al.

Summary: This review article discusses the six most effective Traditional Chinese Medicine recipes used for treating COVID-19 in China, recommending different recipes for different severity of the disease. The article also explores the applications of TCM in treating other viral infections, providing insights for the treatment of COVID-19.

PHARMACOLOGY & THERAPEUTICS (2021)

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Article Immunology

Artemether, Artesunate, Arteannuin B, Echinatin, Licochalcone B and Andrographolide Effectively Inhibit SARS-CoV-2 and Related Viruses In Vitro

Yunjia Hu et al.

Summary: Since the first reported case of novel coronavirus SARS-CoV-2 infection in Wuhan, COVID-19 has caused serious deaths and a global pandemic, with many new variants appearing during continuous transmission. Traditional Chinese medicine has played a significant role in epidemic prevention and clinical treatment in China. Research identified six monomer compounds from traditional Chinese medicine with excellent anti-SARS-CoV-2 activity, providing insights for further research and clinical applications.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Article Pharmacology & Pharmacy

Myricetin Inhibits SARS-CoV-2 Viral Replication by Targeting Mpro and Ameliorates Pulmonary Inflammation

Ting Xiao et al.

Summary: A new SARS-CoV-2 M-pro inhibitor, myricetin, was discovered in this study with potent inhibitory activity through interactions with the enzyme's binding pocket via hydrogen bonds and pi-pi stacking. Myricetin showed strong inhibitory effects on viral replication by binding to SARS-CoV-2 M-pro. Additionally, it exhibited potent inhibitory effects on pulmonary inflammation, making it a potential drug for the treatment of COVID-19 symptoms.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Chemistry, Medicinal

dIdentification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen

Maria Kuzikov et al.

Summary: Compound repurposing is a crucial strategy for identifying effective treatments against SARS-CoV-2 infection and COVID-19. The SARS-CoV-2 main protease, 3CL-Pro, is a promising drug target due to its central role in viral replication. This study identified multiple compounds with potential inhibitory effects on 3CL-Pro, including the compound myricetin which was found to covalently bind to the enzyme and inhibit its activity.

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2021)

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Article Biochemistry & Molecular Biology

Platycodin D, a natural component of Platycodon grandiflorum, prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion

Tai Young Kim et al.

Summary: The study shows that platycodin D (PD) effectively blocks SARS-CoV-2 infection routes by preventing membrane fusion through cholesterol redistribution, suggesting a potent natural product for preventing or treating COVID-19.

EXPERIMENTAL AND MOLECULAR MEDICINE (2021)

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Review Chemistry, Multidisciplinary

Ethnobotany and the Role of Plant Natural Products in Antibiotic Drug Discovery

Gina Porras et al.

Summary: The crisis of antibiotic resistance highlights the importance of exploring plant natural products as a potential source of antibacterial compounds. This review systematically examines the antibacterial activity of 459 plant-derived compounds, with a focus on 183 compounds that show promising potential as antibiotics. The rich chemodiversity and clinical effectiveness of plant NPs make them a valuable resource for future antibiotic discovery and development efforts.

CHEMICAL REVIEWS (2021)

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Review Biochemistry & Molecular Biology

The role of natural products in the prevention and treatment of pulmonary fibrosis: a review

Liqun Wang et al.

Summary: This review summarizes the mechanisms and health benefits of natural products against pulmonary fibrosis, targeting oxidative stress, inflammatory injury, epithelial-mesenchymal transition, fibroblast activation, extracellular matrix accumulation, and metabolic regulation. The mechanisms involve various signaling pathways such as NF-kappa B, TGF-beta 1/Smad, PI3K/Akt, p38 MAPK, Nrf2-Nox4, and AMPK. We aim to provide new ideas for prevention and treatment strategies for pulmonary fibrosis.

FOOD & FUNCTION (2021)

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Article Biochemistry & Molecular Biology

Tutuilamides A-C: Vinyl-Chloride-Containing Cyclodepsipeptides from Marine Cyanobacteria with Potent Elastase Inhibitory Properties

Lena Keller et al.

ACS CHEMICAL BIOLOGY (2020)

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Article Chemistry, Multidisciplinary

Identification of nagilactone E as a protein synthesis inhibitor with anticancer activity

Le-le Zhang et al.

ACTA PHARMACOLOGICA SINICA (2020)

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Article Biochemistry & Molecular Biology

Polyphyllin I activates AMPK to suppress the growth of non-small-cell lung cancer via induction of autophagy

Yezi Wu et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2020)

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Letter Cell Biology

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

Manli Wang et al.

CELL RESEARCH (2020)

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Review Biochemistry & Molecular Biology

Microbiome in Chronic Obstructive Pulmonary Disease: Role of Natural Products against Microbial Pathogens

Alessia Santoro et al.

CURRENT MEDICINAL CHEMISTRY (2020)

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Article Cell Biology

EGCG regulates CTR1 expression through its pro-oxidative property in non-small-cell lung cancer cells

Aochang Chen et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

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Article Plant Sciences

Best practice in research - Overcoming common challenges in phytopharmacological research

Michael Heinrich et al.

JOURNAL OF ETHNOPHARMACOLOGY (2020)

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Article Plant Sciences

Clerodane Diterpenoids Isolated from the Leaves of Casearia graveolens

Feng Liu et al.

JOURNAL OF NATURAL PRODUCTS (2020)

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Article Medicine, General & Internal

A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster

Jasper Fuk-Woo Chan et al.

LANCET (2020)

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Editorial Material Medicine, General & Internal

A novel coronavirus outbreak of global health concern

Chen Wang et al.

LANCET (2020)

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Article Chemistry, Medicinal

PDB-1 from Potentilla discolor Bunge suppresses lung cancer cell migration and invasion via FAK/Src and MAPK signaling pathways

Na-na Meng et al.

MEDICINAL CHEMISTRY RESEARCH (2020)

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Article Oncology

Overcoming acquired resistance of EGFR-mutant NSCLC cells to the third generation EGFR inhibitor, osimertinib, with the natural product honokiol

Hongjing Zang et al.

MOLECULAR ONCOLOGY (2020)

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Article Biochemistry & Molecular Biology

Casticin Induces DNA Damage and Affects DNA Repair Associated Protein Expression in Human Lung Cancer A549 Cells (Running Title: Casticin Induces DNA Damage in Lung Cancer Cells)

Zheng-Yu Cheng et al.

MOLECULES (2020)

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Letter Medicine, General & Internal

Importation and Human-to-Human Transmission of a Novel Coronavirus in Vietnam

Lan T. Phan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Review Pharmacology & Pharmacy

Targeting defective pulmonary innate immunity - A new therapeutic option?

Kylie B. R. Belchamber et al.

PHARMACOLOGY & THERAPEUTICS (2020)

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Article Multidisciplinary Sciences

Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection

Emmie de Wit et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Cell Biology

Deguelin suppresses non-small cell lung cancer by inhibiting EGFR signaling and promoting GSK3β/FBW7-mediated Mcl-1 destabilization

Feng Gao et al.

CELL DEATH & DISEASE (2020)

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Article Multidisciplinary Sciences

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

Timothy P. Sheahan et al.

NATURE COMMUNICATIONS (2020)

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Article Microbiology

Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs

Sangeun Jeon et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2020)

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Article Biochemistry & Molecular Biology

Sinomenine Inhibits Migration and Invasion of Human Lung Cancer Cell through Downregulating Expression of miR-21 and MMPs

Kun-Hung Shen et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Oncology

Formononetin inhibits tumor growth by suppression of EGFR-Akt-Mcl-1 axis in non-small cell lung cancer

Xinyou Yu et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Article Multidisciplinary Sciences

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

Wanchao Yin et al.

SCIENCE (2020)

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Article Virology

The anti-HIV drug nelfinavir mesylate (Viracept) is a potent inhibitor of cell fusion caused by the SARSCoV-2 spike (S) glycoprotein warranting further evaluation as an antiviral against COVID-19 infections

Farhana Musarrat et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

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Review Plant Sciences

Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

David J. Newman et al.

JOURNAL OF NATURAL PRODUCTS (2020)

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Article Plant Sciences

Licochalcone A Selectively Resensitizes ABCG2-Overexpressing Multidrug-Resistant Cancer Cells to Chemotherapeutic Drugs

Chung-Pu Wu et al.

JOURNAL OF NATURAL PRODUCTS (2020)

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Article Biotechnology & Applied Microbiology

Sinomenine Inhibits Non-Small Cell Lung Cancer via Downregulation of Hexokinases II-Mediated Aerobic Glycolysis

Wenbin Liu et al.

ONCOTARGETS AND THERAPY (2020)

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Editorial Material Oncology

TMPRSS2 and COVID-19: serendipity or Opportunity for Intervention?

Konrad H. Stopsack et al.

CANCER DISCOVERY (2020)

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Article Chemistry, Medicinal

Gallic Acid Impedes Non-Small Cell Lung Cancer Progression via Suppression of EGFR-Dependent CARM1-PELP1 Complex

Dong Wang et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2020)

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Article Medicine, General & Internal

Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial

Yeming Wang et al.

LANCET (2020)

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Article Respiratory System

Effects of wogonoside on invasion and migration of lung cancer A549 cells and angiogenesis in xenograft tumors of nude mice

Yubo Yan et al.

JOURNAL OF THORACIC DISEASE (2020)

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Article Oncology

The Inhibitory Mechanisms of Tumor PD-L1 Expression by Natural Bioactive Gallic Acid in Non-Small-Cell Lung Cancer (NSCLC) Cells

Dong Young Kang et al.

CANCERS (2020)

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Article Oncology

Potent Anticancer Effect of the Natural Steroidal Saponin Gracillin Is Produced by Inhibiting Glycolysis and Oxidative Phosphorylation-Mediated Bioenergetics

Hye-Young Min et al.

CANCERS (2020)

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Article Multidisciplinary Sciences

Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

Zhenming Jin et al.

NATURE (2020)

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Editorial Material Biotechnology & Applied Microbiology

The small-cell lung cancer drug market

Joshua B. N. Dawkins et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

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Article Oncology

Hispidulin exhibits potent anticancer activity in vitro and in vivo through activating ER stress in non-small-cell lung cancer cells

Li Lv et al.

ONCOLOGY REPORTS (2020)

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Article Chemistry, Multidisciplinary

Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients

Hai-xia Su et al.

ACTA PHARMACOLOGICA SINICA (2020)

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Article Plant Sciences

Licochalcone A reverses NNK-induced ectopic miRNA expression to elicit in vitro and in vivo chemopreventive effects

Bingxin Li et al.

PHYTOMEDICINE (2020)

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Article Oncology

Icaritin inhibits lung cancer-induced osteoclastogenesis by suppressing the expression of IL-6 and TNF-a and through AMPK/mTOR signaling pathway

Xueqiang Zhao et al.

ANTI-CANCER DRUGS (2020)

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Article Pharmacology & Pharmacy

Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro

Ka-Tim Choy et al.

ANTIVIRAL RESEARCH (2020)

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Article Oncology

Baicalein inhibits non-small-cell lung cancer invasion and metastasis by reducing ezrin tension in inflammation microenvironment

Xiaolong Zhang et al.

CANCER SCIENCE (2020)

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Article Biochemistry & Molecular Biology

Silibinin suppresses epithelial-mesenchymal transition in human non-small cell lung cancer cells by restraining RHBDD1

Suyan Xu et al.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2020)

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Review Pharmacology & Pharmacy

Turning the Tide: Natural Products and Natural-Product-Inspired Chemicals as Potential Counters to SARS-CoV-2 Infection

Zhonglei Wang et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Medicine, Research & Experimental

Liriopesides B induces apoptosis and cell cycle arrest in human non-small cell lung cancer cells

Hongxu Sheng et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2020)

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Article Chemistry, Medicinal

Anti-SARS-CoV-2 Potential of Artemisinins In Vitro

Ruiyuan Cao et al.

ACS INFECTIOUS DISEASES (2020)

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Article Cell Biology

Dioscin elicits anti-tumour immunity by inhibiting macrophage M2 polarization via JNK and STAT3 pathways in lung cancer

Luyun Cui et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Review Cell Biology

Versatile role of curcumin and its derivatives in lung cancer therapy

Milad Ashrafizadeh et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

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Review Cell Biology

Molecular Mechanisms of Cardiomyocyte Death in Drug-Induced Cardiotoxicity

Wanjun Ma et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Article Nanoscience & Nanotechnology

Engineering EHD1-Targeted Natural Borneol Nanoemulsion Potentiates Therapeutic Efficacy of Gefitinib against Nonsmall Lung Cancer

Riming Yuan et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Physical

Enhanced solubility, stability, permeation and anti-cancer efficacy of Celastrol-β-cyclodextrin inclusion complex

Snehal K. Shukla et al.

JOURNAL OF MOLECULAR LIQUIDS (2020)

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Article Biochemistry & Molecular Biology

EGCG sensitizes chemotherapeutic-induced cytotoxicity by targeting the ERK pathway in multiple cancer cell lines

Ran Wei et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2020)

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Article Oncology

Direct targeting of HSP90 with daurisoline destabilizes beta-catenin to suppress lung cancer tumorigenesis

Xiao-Hui Huang et al.

CANCER LETTERS (2020)

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Article Chemistry, Applied

β-Cyclodextrin-modified hyaluronic acid-based supramolecular self-assemblies for pH- and esterase-dual-responsive drug delivery

Yang Bai et al.

CARBOHYDRATE POLYMERS (2020)

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Article Multidisciplinary Sciences

Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2

Brandi N. Williamson et al.

NATURE (2020)

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Article Multidisciplinary Sciences

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

Donghyuk Shin et al.

NATURE (2020)

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Article Oncology

Parthenolide inhibits human lung cancer cell growth by modulating the IGF-1R/PI3K/Akt signaling pathway

Longhua Sun et al.

ONCOLOGY REPORTS (2020)

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Article Oncology

Xanthohumol targets the ERK1/2-Fra1 signaling axis to reduce cyclin D1 expression and inhibit non-small cell lung cancer

Feng Gao et al.

ONCOLOGY REPORTS (2020)

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Article Integrative & Complementary Medicine

Triterpenoids from the Leaves of Centella asiatica Inhibit Ionizing Radiation-Induced Migration and Invasion of Human Lung Cancer Cells

Ah-Reum Han et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2020)

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Article Integrative & Complementary Medicine

Tea Polyphenols EGCG and Theaflavin Inhibit the Activity of SARS-CoV-2 3CL-Protease In Vitro

Minsu Jang et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2020)

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Article Cell Biology

The circadian clock gene Bmal1 facilitates cisplatin-induced renal injury and hepatization

Min Zha et al.

CELL DEATH & DISEASE (2020)

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Article Chemistry, Medicinal

Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment

Victoria C. Yan et al.

ACS MEDICINAL CHEMISTRY LETTERS (2020)

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Article Multidisciplinary Sciences

In vitro screening of a FDA approved chemical library reveals potential inhibitors of SARS-CoV-2 replication

Franck Touret et al.

SCIENTIFIC REPORTS (2020)

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Editorial Material Medicine, General & Internal

Efficacy of Remdesivir in COVID-19

Erin K. McCreary et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Article Chemistry, Medicinal

Chinese Therapeutic Strategy for Fighting COVID-19 and Potential Small-Molecule Inhibitors against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

Namrta Choudhry et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

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Article Chemistry, Physical

Structural and therapeutic properties of curcumin solubilized pluronic F127 micellar solutions and hydrogels

R. Ganguly et al.

JOURNAL OF MOLECULAR LIQUIDS (2020)

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Article Multidisciplinary Sciences

Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion

Donald J. Benton et al.

NATURE (2020)

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Article Multidisciplinary Sciences

Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein

Christine Toelzer et al.

SCIENCE (2020)

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Article Chemistry, Multidisciplinary

An Activatable Nano-Prodrug for Treating Tyrosine-Kinase-Inhibitor-Resistant Non-Small Cell Lung Cancer and for Optoacoustic and Fluorescent Imaging

Xin Xie et al.

SMALL (2020)

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Article Pharmacology & Pharmacy

Natural alkaloid 8-oxo-epiberberine inhibited TGF-beta 1-triggred epithelial-mesenchymal transition by interfering Smad3

Xin Liu et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2020)

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Review Pharmacology & Pharmacy

Anti-SARS-CoV Natural Products With the Potential to Inhibit SARS-CoV-2 (COVID-19)

Surjeet Verma et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Respiratory System

Fatal toxic effects related to EGFR tyrosine kinase inhibitors based on 53 cohorts with 9,569 participants

Xianhe Xie et al.

JOURNAL OF THORACIC DISEASE (2020)

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Article Biochemistry & Molecular Biology

Ahp-Cyclodepsipeptides as tunable inhibitors of human neutrophil elastase and kallikrein 7: Total synthesis of tutuilamide A, serine protease selectivity profile and comparison with lyngbyastatin 7

Qi-Yin Chen et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2020)

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Article Oncology

Parthenolide inhibits the growth of non-small cell lung cancer by targeting epidermal growth factor receptor

Xiaoling Li et al.

CANCER CELL INTERNATIONAL (2020)

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Article Chemistry, Physical

Comparison of Redox Responsiveness and Antitumor Capability of Paclitaxel Dimeric Nanoparticles with Different Linkers

Jian Wang et al.

CHEMISTRY OF MATERIALS (2020)

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Editorial Material Medicine, General & Internal

FDA Approval of Remdesivir - A Step in the Right Direction

Daniel Rubin et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Cell Biology

A cross-talk between epithelium and endothelium mediates human alveolar-capillary injury during SARS-CoV-2 infection

Peng Wang et al.

CELL DEATH & DISEASE (2020)

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Editorial Material Medicine, General & Internal

Remdesivir: a pendulum in a pandemic

Ilan S. Schwartz et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

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Review Biochemistry & Molecular Biology

ACE2: the molecular doorway to SARS-CoV-2

Miriam Marlene Medina-Enriquez et al.

CELL AND BIOSCIENCE (2020)

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Article Plant Sciences

Docking Characterization and in vitro Inhibitory Activity of Flavan-3-ols and Dimeric Proanthocyanidins Against the Main Protease Activity of SARS-Cov-2

Yue Zhu et al.

FRONTIERS IN PLANT SCIENCE (2020)

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Article Pharmacology & Pharmacy

Self-Assembled Disulfide Bond Bearing Paclitaxel-Camptothecin Prodrug Nanoparticle for Lung Cancer Therapy

Jingyan Gao et al.

PHARMACEUTICS (2020)

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Article Biochemistry & Molecular Biology

Isoharringtonine Induces Apoptosis of Non-Small Cell Lung Cancer Cells in Tumorspheroids via the Intrinsic Pathway

Ji Hae Lee et al.

BIOMOLECULES (2020)

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Article Biochemistry & Molecular Biology

Baicalein suppresses vasculogenic mimicry through inhibiting RhoA/ROCK expression in lung cancer A549 cell line

Zhe Zhang et al.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2020)

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Article Biochemistry & Molecular Biology

Phenolic compound ellagic acid inhibits mitochondrial respiration and tumor growth in lung cancer

Jing Duan et al.

FOOD & FUNCTION (2020)

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Review Chemistry, Multidisciplinary

GS-5734: a potentially approved drug by FDA against SARS-Cov-2

Zhonglei Wang et al.

NEW JOURNAL OF CHEMISTRY (2020)

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Article Biochemistry & Molecular Biology

Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis

Peng Chen et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Article Cell Biology

Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer

Lu Zhang et al.

AUTOPHAGY (2019)

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Article Oncology

Axl is a novel target of celastrol that inhibits cell proliferation and migration, and increases the cytotoxicity of gefitinib in EGFR mutant non-small cell lung cancer cells

Youn Ju Lee et al.

MOLECULAR MEDICINE REPORTS (2019)

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Article Chemistry, Analytical

Fluorescent probe for sensitive discrimination of Hcy and Cys/GSH in living cells via dual-emission

Shuang Xu et al.

ANALYTICA CHIMICA ACTA (2019)

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Article Cell Biology

Remdesivir (GS-5734) protects African green monkeys from Nipah virus challenge

Michael K. Lo et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

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Review Biochemistry & Molecular Biology

Cisplatin: The first metal based anticancer drug

Sumit Ghosh

BIOORGANIC CHEMISTRY (2019)

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Article Infectious Diseases

Characterisation of infectious Ebola virus from the ongoing outbreak to guide response activities in the Democratic Republic of the Congo: a phylogenetic and in vitro analysis

Laura K. McMullan et al.

LANCET INFECTIOUS DISEASES (2019)

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Review Plant Sciences

Cepharanthine: An update of its mode of action, pharmacological properties and medical applications

Christian Bailly

PHYTOMEDICINE (2019)

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Article Biochemistry & Molecular Biology

Natural Bis-Benzylisoquinoline Alkaloids-Tetrandrine, Fangchinoline, and Cepharanthine, Inhibit Human Coronavirus OC43 Infection of MRC-5 Human Lung Cells

Dong Eon Kim et al.

BIOMOLECULES (2019)

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Article Oncology

Autophagy flux inhibition mediated by celastrol sensitized lung cancer cells to TRAIL-induced apoptosis via regulation of mitochondrial transmembrane potential and reactive oxygen species

Uddin Md Nazim et al.

MOLECULAR MEDICINE REPORTS (2019)

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Article Virology

Characterization of the Lipidomic Profile of Human Coronavirus-Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus Replication

Bingpeng Yan et al.

VIRUSES-BASEL (2019)

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Article Oncology

Celastrol improves the therapeutic efficacy of EGFR-TKIs for non-small-cell lung cancer by overcoming EGFR T790M drug resistance

Ying Wang et al.

ANTI-CANCER DRUGS (2018)

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Article Chemistry, Medicinal

Progress in the Development of Preventative Drugs for Cisplatin-Induced Hearing Loss

Robert A. Hazlitt et al.

JOURNAL OF MEDICINAL CHEMISTRY (2018)

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Article Plant Sciences

Curcumin enhances cisplatin sensitivity of human NSCLC cell lines through influencing Cu-Sp1-CTR1 regulatory loop

Wei Zhang et al.

PHYTOMEDICINE (2018)

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Review Food Science & Technology

Impact of curcumin nanoformulation on its antimicrobial activity

Anderson Clayton da Silva et al.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2018)

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Article Cell Biology

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

Timothy P. Sheahan et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

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Article Medicine, General & Internal

Late Ebola virus relapse causing meningoencephalitis: a case report

Michael Jacobs et al.

LANCET (2016)

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Article Multidisciplinary Sciences

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

Travis K. Warren et al.

NATURE (2016)

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Review Immunology

Control of autoimmune inflammation by celastrol, a natural triterpenoid

Shivaprasad H. Venkatesha et al.

PATHOGENS AND DISEASE (2016)

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Editorial Material Multidisciplinary Sciences

Chemical con artists foil drug discovery

Jonathan Baell et al.

NATURE (2014)

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Article Chemistry, Medicinal

Targeted Polysaccharide Nanoparticle for Adamplatin Prodrug Delivery

Yang Yang et al.

JOURNAL OF MEDICINAL CHEMISTRY (2013)

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Natural Products, Alone or in Combination with FDA-Approved Drugs, to Treat COVID-19 and Lung Cancer

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