Journal
BIOMEDICINES
Volume 9, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines9060596
Keywords
complex regional pain syndrome; chronic post-ischemic pain; URB597; pyrrolidine dithiocarbamate; hydralazine
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Funding
- Kim Myung-Sun Foundation
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The study compared the pain relief effects of different drugs in a rat model of chronic post-ischemic pain-induced CRPS, finding that these drugs effectively alleviated CRPS-induced mechanical allodynia, improved mechanical sensitivity, and reduced the expression of inflammatory factors.
Complex regional pain syndrome (CRPS) describes an array of painful conditions that are characterized by continuing regional pain. CRPS comprises severe and inappropriate pain in cases of complete recovery after trauma. Research on the pharmacological treatment of CRPS, however, has not been well investigated. In this study, we compared the pain relief effects of different drugs (URB597, pyrrolidine dithiocarbamate, and hydralazine) in a rat model of chronic post-ischemic pain-induced CRPS. After drug injection, CRPS-induced mechanical allodynia was significantly recovered. After three repetitive drug injections, mechanical sensitivity generally improved as hyper-nociception subsided. Reduced Nav1.7 expression at dorsal root ganglions (DRGs) was observed in the drug treatment groups. Neural imaging analysis revealed decreased neural activity for each drug treatment, compared to vehicle. In addition, treatments significantly reduced IL-1 beta, IL-6, and TNF alpha expression in DRGs. These results indicated that drugs could reduce the expression of inflammatory factors and alleviate the symptoms of chronic post-ischemic pain-induced CRPS.
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