Journal
BIOMEDICINES
Volume 9, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines9060653
Keywords
CD4; CD8; FOXP3; OCT4; Nestin; Podoplanin; TILs; oral cancer
Categories
Funding
- Instituto de Salud Carlos III [PI19/01255, PI19/00560, CIBERONC CB16/12/00390]
- Instituto de Investigacion Sanitaria del Principado de Asturias (ISPA), Ayudas a Grupos PCTI Principado de Asturias [IDI2018/155]
- Fundacion Bancaria Caja de Ahorros de Asturias-IUOPA
- FEDER Funding Program from the European Union
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This study found that TILs in OSCC patients were associated with PD-L1 expression and CSC markers. CD4(+) and CD8(+) TILs were related to smoking and alcohol habits. High infiltration of CD4(+) and CD8(+) TILs was significantly associated with tumors harboring positive PD-L1 expression.
This study investigates the relevance of tumor-infiltrating lymphocytes (TILs) in oral squamous cell carcinoma (OSCC). Immunohistochemical analysis of stromal/tumoral CD4(+), CD8(+) and FOXP3(+) TILs is performed in 125 OSCC patients. Potential relationships with the expression of tumoral PD-L1 and cancer stem cell (CSC) markers (NANOG, SOX2, OCT4, Nestin and Podoplanin (PDPN)) are assessed. CD4(+) and CD8(+) TILs are significantly associated with smoking and alcohol habits. CD4(+) and CD8(+) TILs show an inverse relationship with NANOG and SOX2 expression, and FOXP3(+) TILs is significantly correlated with Nestin and PDPN expression. High infiltration of CD4(+) and CD8(+) TILs and a high tumoral CD8(+)/FOXP3(+) ratio are significantly associated with tumors harboring positive PD-L1 expression. Infiltration of stromal/tumoral FOXP3(+) TILs and a low stromal CD8(+)/FOXP3(+) ratio are significantly associated with better disease-specific survival. Multivariate analysis reveals that the stromal CD8(+)/FOXP3(+) TILs ratio is a significant independent prognostic factor. Regarding OSCC patient survival, the CD8(+)/FOXP3(+) TILs ratio is an independent prognostic factor. TILs may act as biomarkers and potential therapeutic targets for OSCC.
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