Journal
BIOMEDICINES
Volume 9, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines9060612
Keywords
Scavenger receptor B class 1; cardiovascular disease; mice and human genetic studies; high-density lipoprotein; low-density lipoprotein
Categories
Funding
- Gobierno de Aragon, Spain [B14-7R]
- Spanish Ministry of Science and Innovation [PI18/01777, PI19/00694]
- CIBERCV
- European Regional Development Fund (ERDF) of the European Union A way to make Europe
- Sara Borrell fellowship [CD19/00245]
- Instituto de Salud Carlos III
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High levels of LDL in plasma drive the initiation and progression of CVD, while HDL is considered anti-atherogenic. SR-B1, as the high-affinity HDL receptor, plays a crucial role in the metabolism of various lipoproteins.
High plasma level of low-density lipoprotein (LDL) is the main driver of the initiation and progression of cardiovascular disease (CVD). Nevertheless, high-density lipoprotein (HDL) is considered an anti-atherogenic lipoprotein due to its role in reverse cholesterol transport and its ability to receive cholesterol that effluxes from macrophages in the artery wall. The scavenger receptor B class type 1 (SR-B1) was identified as the high-affinity HDL receptor, which facilitates the selective uptake of cholesterol ester (CE) into the liver via HDL and is also implicated in the plasma clearance of LDL, very low-density lipoprotein (VLDL) and lipoprotein(a) (Lp(a)). Thus, SR-B1 is a multifunctional receptor that plays a main role in the metabolism of different lipoproteins. The aim of this review is to highlight the association between SR-B1 and CVD risk through mice and human genetic studies.
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