Journal
BIOMEDICINES
Volume 9, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines9080937
Keywords
kidney transplantation; post-transplant cancer; colorectal cancer; colonoscopy; screening; healthy; adenoma; cancer
Categories
Funding
- University of Catania
- School in General Surgery of the University of Catania
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Kidney transplant recipients do not have an increased risk of developing colorectal cancer compared to the healthy population, but they have a higher risk of developing colorectal adenomas.
The incidence of colorectal cancer in kidney transplant recipients has been previously reported with conflicting results. In this study, we investigated if the incidence of colorectal advanced neoplasms in kidney transplant recipients, evaluated with screening colonoscopy, was higher than in healthy individuals. One-hundred sixty kidney transplant recipients undergoing screening colonoscopy were compared with 594 age- and sex-matched healthy individuals. Advanced colorectal neoplasia was found in 22 patients (13.7%), including four patients (2.5%) with colorectal cancer. Compared with the healthy population, kidney transplant recipients did not have an increased risk of developing a colorectal cancer (OR 0.69; 95% CI 0.236-2.063, p = 0.688) although it developed at a younger age. In contrast, kidney transplant recipients had a higher risk of developing an advanced adenoma compared with the control group (OR 1.65; 95% CI 0.930-2.981, p = 0.04). In conclusion, kidney transplant recipients did not have an increased incidence of colorectal cancer compared with healthy population. However, transplant patients displayed a higher incidence of colorectal adenomas, suggesting that screening colonoscopy in kidney transplant recipients should be expanded to include even younger recipients (<50 years old).
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