Journal
BIOMEDICINES
Volume 9, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines9070821
Keywords
activin signaling pathway; ACVR1B (Activin A Receptor Type 1B); pancreatic cancer; PDAC (pancreatic ductal adenocarcinoma); tumor suppression; context-dependent; TGF beta superfamily; therapeutic target
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Funding
- NIH/NCI [R01 CA217207]
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Activin, a member of the TGF-beta superfamily, is involved in various physiological processes and human diseases, particularly in tumorigenesis where it plays both tumor-suppressor and tumor-promoter roles. Understanding the mechanisms of activin signaling in tumorigenesis could lead to potential therapeutic targets for human cancers and other diseases.
Activin, a member of the TGF-beta superfamily, is involved in many physiological processes, such as embryonic development and follicle development, as well as in multiple human diseases including cancer. Genetic mutations in the activin signaling pathway have been reported in many cancer types, indicating that activin signaling plays a critical role in tumorigenesis. Recent evidence reveals that activin signaling may function as a tumor-suppressor in tumor initiation, and a promoter in the later progression and metastasis of tumors. This article reviews many aspects of activin, including the signaling cascade of activin, activin-related proteins, and its role in tumorigenesis, particularly in pancreatic cancer development. The mechanisms regulating its dual roles in tumorigenesis remain to be elucidated. Further understanding of the activin signaling pathway may identify potential therapeutic targets for human cancers and other diseases.
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